ADN2_SCHPO
ID ADN2_SCHPO Reviewed; 743 AA.
AC O94619;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Adhesion defective protein 2;
DE AltName: Full=LisH domain-containing protein adn2;
GN Name=adn2; ORFNames=SPBC1289.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
RN [4]
RP FUNCTION.
RX PubMed=19542312; DOI=10.1128/ec.00078-09;
RA Dodgson J., Avula H., Hoe K.L., Kim D.U., Park H.O., Hayles J.,
RA Armstrong J.;
RT "Functional genomics of adhesion, invasion, and mycelial formation in
RT Schizosaccharomyces pombe.";
RL Eukaryot. Cell 8:1298-1306(2009).
CC -!- FUNCTION: Probable transcriptional regulator involved in cell adhesion.
CC {ECO:0000269|PubMed:19542312}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FLO8 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB38690.1; -; Genomic_DNA.
DR PIR; T39361; T39361.
DR RefSeq; NP_596834.1; NM_001023855.2.
DR AlphaFoldDB; O94619; -.
DR BioGRID; 276726; 52.
DR STRING; 4896.SPBC1289.10c.1; -.
DR iPTMnet; O94619; -.
DR MaxQB; O94619; -.
DR PaxDb; O94619; -.
DR PRIDE; O94619; -.
DR EnsemblFungi; SPBC1289.10c.1; SPBC1289.10c.1:pep; SPBC1289.10c.
DR GeneID; 2540193; -.
DR KEGG; spo:SPBC1289.10c; -.
DR PomBase; SPBC1289.10c; adn2.
DR VEuPathDB; FungiDB:SPBC1289.10c; -.
DR eggNOG; ENOG502R28W; Eukaryota.
DR HOGENOM; CLU_376492_0_0_1; -.
DR InParanoid; O94619; -.
DR OMA; FLIEWWN; -.
DR PhylomeDB; O94619; -.
DR PRO; PR:O94619; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; ISO:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:PomBase.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:PomBase.
DR InterPro; IPR006594; LisH.
DR Pfam; PF08513; LisH; 1.
DR SMART; SM00667; LisH; 1.
DR PROSITE; PS50896; LISH; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..743
FT /note="Adhesion defective protein 2"
FT /id="PRO_0000303959"
FT DOMAIN 38..70
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 743 AA; 81159 MW; B55B4B71A85B4398 CRC64;
MADPGLRSGV GLPSQQGQKH DLQKDQKQPH VNNADRTTQS LLNSYIYDYL IKKDYCEAAR
AFGREAQVQT LVRSQEETNS LAKRHKRMSP VAVKHEGISN NESSDENMNV NNGNLDSFSS
SSAPPPPPIL PIDSAGGFLI EWWNVFWDIY NARRGQGSEP AKAYMSHISN LRKKSRLNLQ
EIQKNSLHTG NTSHPYANAS FPHDPANAMG QQIDSSQFHQ GAGGLNDRNQ HLMRQAMLNN
QSRETFPPTA AQLQQLKQLH YRQLQSVQQQ QKQHQQKKTP QSGSTPQMQN TTSQPTTHDT
HPPKQQGPIS DFRSIPSSPK TEGAPSNAQF RPSLPATPNG SVPQSNPLYD TTGLNGGQYP
VVQNSAQPLL HEINFASNRN PHLKQGGAVP SSTLPQQQKS LDKPKPAQQP STGQFSGNQM
NQYGFSNSPY SQNMLYNFNG NANPSRLNPA LKNYMEELKL LEQQNKKRLL LVSQEKERKG
YTSASPDRPL SQTITESSVA KTKSTTPKST DTPTEATTSP VKVSTKNSNT TENLNGINES
NMPMLQNGLP LRTSGDHPSN YSNLIENSST SDTNNADNGM DVMGNWQLQQ THSSRPTPNA
SSPLDVRSKQ KPSSANSNAP TPAPTVNTTN PESSTNEATS VGPALEPSQG ANVHKSDSEL
DNQNQSGKSN PDTSATPSAP TESTTVATKS SDNQLLDVGN STDIDAALLN DFDFDKFLKD
TSTGDDLWFG LFNLPDNEDS TAA
