ID   E5_VACCC                Reviewed;         341 AA.
AC   P21046;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   23-FEB-2022, entry version 64.
DE   RecName: Full=Protein E5;
GN   ORFNames=E5R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Major early protein present in virus factories.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Note=Localizes in
CC       cytoplasmic virus factories. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48042.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M35027; AAA48042.1; ALT_FRAME; Genomic_DNA.
DR   PIR; I42508; I42508.
DR   SMR; P21046; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   InterPro; IPR018379; BEN_domain.
DR   InterPro; IPR004334; Poxvirus_E5R.
DR   Pfam; PF10523; BEN; 2.
DR   PIRSF; PIRSF015691; VAC_E5R; 1.
DR   PROSITE; PS51457; BEN; 2.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Reference proteome; Repeat.
FT   CHAIN           1..341
FT                   /note="Protein E5"
FT                   /id="PRO_0000099450"
FT   DOMAIN          112..222
FT                   /note="BEN 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT   DOMAIN          233..328
FT                   /note="BEN 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
SQ   SEQUENCE   341 AA;  40316 MW;  A2BB5C913C522AA0 CRC64;
     MLILTKVNIY MLIIVLWLYG YNFIMSGSQC PMINDDSFTL KRKYQIDSAE STMKMDKKRT
     KFQNRAKMVK EINQTIRAAQ THYETLKLGY IKFKRMIRTT TLEDIAPSIP NNQKTYKLFS
     DISAIGKASQ NPSKMVYALL LYMFPNLFGD DHRFIRYRMH PMSKIKHKIF SPFKLNLIRI
     LVEERFYNNE CRSNKWRIIG TQVDKMLIAE SDKYTIDARY NLKPMYRIKG KSEEDTLFIK
     QMVEQCVTSQ ELVEKVLKIL FRDLFKSGEY KAYRYDDDVE NGFIGLDTLK LNIVHDIVEP
     CMPVRRPVAK ILCKEMVNKY FENPLHIIGK NLQECIDFVS E