ID   E5_VACCD                Reviewed;         341 AA.
AC   Q01478;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   23-FEB-2022, entry version 46.
DE   RecName: Full=Protein E5;
GN   ORFNames=E5R;
OS   Vaccinia virus (strain Dairen I) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10250;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1331540; DOI=10.1128/jvi.66.12.7565-7567.1992;
RA   Douglass N., Dumbell K.;
RT   "Independent evolution of monkeypox and variola viruses.";
RL   J. Virol. 66:7565-7567(1992).
CC   -!- FUNCTION: Major early protein present in virus factories.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Note=Localizes in
CC       cytoplasmic virus factories. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E5 family. {ECO:0000305}.
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DR   EMBL; M95535; AAA48234.1; -; Genomic_DNA.
DR   SMR; Q01478; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   InterPro; IPR018379; BEN_domain.
DR   InterPro; IPR004334; Poxvirus_E5R.
DR   Pfam; PF10523; BEN; 2.
DR   PIRSF; PIRSF015691; VAC_E5R; 1.
DR   PROSITE; PS51457; BEN; 2.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Repeat.
FT   CHAIN           1..341
FT                   /note="Protein E5"
FT                   /id="PRO_0000099451"
FT   DOMAIN          112..222
FT                   /note="BEN 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT   DOMAIN          233..328
FT                   /note="BEN 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
SQ   SEQUENCE   341 AA;  40437 MW;  09FE2F193FFD5541 CRC64;
     MLILTKVNIY MLIIVLWLYG HNFIMSESQC PMINDDSFTL KRKYQIDSAE STIKMDKKRI
     KFQNRAKMVK EINQTIRVAQ THYETLKLGY IKFKRMIRTT TLEDIAPSIP NNQKTYKLFS
     DISAIGKASQ NPSKMVYALL LYMFPNLFGD DHRFIRYRMH PMSKIKHKIF SPFKLNLIRI
     LVEERFYNNE CRSNKWRIIG TQVDKMLIAE SDKYTIDARY RLRPIYRIKG KSEEDTLFIK
     QMVEQCVTSQ ELVEKVLKIL FRDLFKSGEY KAYRYDDDVE NGFIGLDTLK LNIVHDIVEP
     CMPVRRPVAK ILCKEMVNKY FENPLHIIGK NLQECIDFVS E