ID   E5_VARV                 Reviewed;         341 AA.
AC   P0DSS4; Q01483;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Protein E5;
GN   ORFNames=E5R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Harvey, and Somalia;
RX   PubMed=1331540; DOI=10.1128/jvi.66.12.7565-7567.1992;
RA   Douglass N., Dumbell K.;
RT   "Independent evolution of monkeypox and variola viruses.";
RL   J. Virol. 66:7565-7567(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
CC   -!- FUNCTION: Major early protein present in virus factories.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Note=Localizes in
CC       cytoplasmic virus factories. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E5 family. {ECO:0000305}.
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DR   EMBL; M95532; AAA48351.1; -; Genomic_DNA.
DR   EMBL; M95533; AAA48352.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA48987.1; -; Genomic_DNA.
DR   PIR; T28484; T28484.
DR   RefSeq; NP_042090.1; NC_001611.1.
DR   SMR; P0DSS4; -.
DR   GeneID; 1486411; -.
DR   KEGG; vg:1486411; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   InterPro; IPR018379; BEN_domain.
DR   InterPro; IPR004334; Poxvirus_E5R.
DR   Pfam; PF10523; BEN; 2.
DR   PIRSF; PIRSF015691; VAC_E5R; 1.
DR   PROSITE; PS51457; BEN; 2.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Repeat.
FT   CHAIN           1..341
FT                   /note="Protein E5"
FT                   /id="PRO_0000448179"
FT   DOMAIN          112..222
FT                   /note="BEN 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT   DOMAIN          233..328
FT                   /note="BEN 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00784"
FT   VARIANT         209
FT                   /note="A -> V (in strain: Harvey and Somalia)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   341 AA;  40463 MW;  B3348D7708CCA412 CRC64;
     MLILTKVNIY MLIIVLWLYG YNFIMSGSQC PMINDDRFTL KRKYQIDSVE STMKMDKKRT
     KFQNRAKMVK EINQTIRAAQ THYETLKLGY IKFKKMIRTT TLEDITTSIP NIQKIYKLFS
     DISAIGKVSQ NPSKMAYALL LYMFPNLFGD DHRFILYRMF PMSKIKHKIF SPFKLNLIRI
     LVEERFYNNE CRSNKWRIIG TQVDKMLIAE SDKYTIDARY RLRPIYRIKG KSEEDTLFIK
     QMVDQCVTSQ ELVEKVLKIL FRDLFKSGEY KAYRYDDDVE NGFIGLDKLK LNIVHDIVEP
     CMPVRRPVAK ILCKEMVNKY FENPLHIIGK NLQECIDFVS E