ID   E6_VACCC                Reviewed;         567 AA.
AC   P21047;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 62.
DE   RecName: Full=Protein E6;
GN   Name=E6R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Late protein which may play a role in the virion
CC       morphogenesis and have therefore an indirect role on viral
CC       transcription ability.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Localizes in the mature virion (MV).
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E6 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48044.1; -; Genomic_DNA.
DR   PIR; A42509; A42509.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR006749; Pox_E6.
DR   Pfam; PF04656; Pox_E6; 1.
DR   PIRSF; PIRSF015629; VAC_E6R; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..567
FT                   /note="Protein E6"
FT                   /id="PRO_0000099454"
SQ   SEQUENCE   567 AA;  66670 MW;  CE92CEE927F5CF41 CRC64;
     MDFIRRKYLI YTVENNIDFL KDDTLSKVNN FTLNHVLALK YLVSNFPQHV ITKDVLANTN
     FFVFIHMVRC CKVYEAVLRH AFDAPTLYVK ALTKNYLSFS NAIQSYKETV HKLTQDEKFL
     EVAEYMDELG ELIGVNYDLV LNPLFHGGEP IKDMEIIFLK LFKKTDFKVV KKLSVIRLLI
     WAYLSKKDTG IEFADNDRQD IYTLFQQTGR IVHSNLTETF RDYIFPGDKT SYWVWLNESI
     ANDADIVLNR HAITMYDKIL SYIYSEIKQG RVNKNMLKLV YIFEPEKDIR ELLLEIIYDI
     PGDILSIIDA KNDDWKKYFI SFYKANFING NTFISDRTFN EDLFRVVVQI DPEYFDNERI
     MSLFSTSAAD IKRFDELDIN NSYISNIIYE VNDITLDTMD DMKKCQIFNE DTSYYVKEYN
     TYLFLHESDP MVIENGILKK LSSIKSKSKR LNLFSKNILK YYLDGQLARL GLVLDDYKGD
     LLVKMINHLK SVEDVSAFVR FSTDKNPSIL PSLIKTILAS YNISIIVLFQ RFLRDNLYHV
     EEFLDKSIHL TKTDKKYILQ LIRHGRS