ID   E6_VAR67                Reviewed;         567 AA.
AC   P0DSX1; P33819;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 6.
DE   RecName: Full=Protein E6;
GN   Name=E6R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Late protein which may play a role in the virion
CC       morphogenesis and have therefore an indirect role on viral
CC       transcription ability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes in the
CC       mature virion (MV). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E6 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA48988.1; -; Genomic_DNA.
DR   PIR; I36841; I36841.
DR   RefSeq; NP_042091.1; NC_001611.1.
DR   GeneID; 1486412; -.
DR   KEGG; vg:1486412; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR006749; Pox_E6.
DR   Pfam; PF04656; Pox_E6; 1.
DR   PIRSF; PIRSF015629; VAC_E6R; 1.
PE   2: Evidence at transcript level;
KW   Late protein; Reference proteome; Virion.
FT   CHAIN           1..567
FT                   /note="Protein E6"
FT                   /id="PRO_0000099456"
SQ   SEQUENCE   567 AA;  66717 MW;  2F64C6D52477082D CRC64;
     MDFIRRKYLI YTVENNIDFL KDDTLSKVNN FTLNHVLALK YLVSNFPQHV ITKDVLANTN
     FFVFIHMVRC CKVYEAVLRH AFDAPTLYVK ALTKNYLSFS NAIQSYKETV HKLTQDEKFL
     EVAEYMEELG ELIGVNYDLV LNPLFHGGEP IKDMEIIFLK LFKKTDFKVV KKLSVIRLLI
     WAYLSKKDTG IEFADNDRQD IYTLFQHTGR IVHSNLTETF RDYIFPGDKT SYWVWLNESI
     ANDADIVLNR PAITMYDKIL SYIYSEIKQG RVNKNMLKLV YIFEPEKDIR ELLLEIIYDI
     PGDILSIIDA KNDDWKKYFI SFYKANFING NTFISDRTFN EDLFRVVVQI DPEYFDNERI
     MSLFSTSAVE IKRFDELDIN NSYISNIIYE VNDITLDTMD DMKKCQIFNE DTSYYVKEYN
     TYLFLNETDP MVIENGILKK LSSIKSKSRR LNLFSKNILK YYLDGQLARL GLVLDDYKGD
     LLVKMINHLK FVEDVSAFVR FSTDKNPSVL PSLINTILAS YNISIIVLFQ KFLRDNLYHV
     EKFLDKSIHL TKTDKKYILQ LIRHGRS