ID   E74EF_DROVI             Reviewed;         873 AA.
AC   Q7M3M6;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Ecdysone-induced protein 74EF;
DE   AltName: Full=ETS-related protein E74A;
GN   Name=Eip74EF; Synonyms=e74;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE, AND INDUCTION.
RX   PubMed=2016053; DOI=10.1093/genetics/127.3.535;
RA   Jones C.W., Dalton M.W., Townley L.H.;
RT   "Interspecific comparisons of the structure and regulation of the
RT   Drosophila ecdysone-inducible gene E74.";
RL   Genetics 127:535-543(1991).
CC   -!- FUNCTION: Probably acts as a transcription factor during metamorphosis.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- INDUCTION: The expression of this protein is developmentally regulated
CC       and is correlated with the 20-OH-ecdysone induced activity of puff
CC       74EF. {ECO:0000269|PubMed:2016053}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   PIR; B53225; B53225.
DR   AlphaFoldDB; Q7M3M6; -.
DR   SMR; Q7M3M6; -.
DR   STRING; 7244.FBpp0227516; -.
DR   eggNOG; KOG3804; Eukaryota.
DR   ChiTaRS; Eip74EF; fly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:EnsemblMetazoa.
DR   GO; GO:0035071; P:salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
DR   GO; GO:0007283; P:spermatogenesis; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; DNA-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..873
FT                   /note="Ecdysone-induced protein 74EF"
FT                   /id="PRO_0000204084"
FT   DNA_BIND        777..859
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          321..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..485
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          605..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          45..155
FT                   /evidence="ECO:0000255"
FT   COILED          330..426
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        448..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   873 AA;  94631 MW;  3EB81198D968D3B0 CRC64;
     MPFIDDALLW CPDNDGRLVG GLDLATCITD DSTVDAENIN PTIGANSSTL QQQQQLQQQQ
     LQQQQLQQQQ QQLQQLQQHQ QQQQQQQQSA DLCGSAARNV NVVVEPLCGS DSSDELFRTL
     SESNFEIESL LSDLATVEVK VENEENNNNN NSNVISDNDF AASQAAVVAG DDLLAKDNVQ
     LSVQGLVDSV GARSADSGSG NGHGQALLAF GSATATATAA SSRMVSFVTC RTTESMQINI
     LFGFRLGFLL PCDLLNNNNN SNNNGSNGNG NGNGRCTPEE SRFVTVTSAS ANPLLVEKLM
     SKCLNIDKRN DKLDDTEIPI VKQSTSPSPH QQQQQHQHQQ QQQQQQQQHL QQTQQQQQQQ
     QQQQQQQQQQ QVFGSATTLL HIKTEQNALL TPLQQSQQQQ QQQQQQQQQH SLQANNNAHQ
     QQQQQQPLAI PHRPLLHNLL SGGAIHNPHH RNYTTATTGS FPPSPADSGV SDVDSSSSGG
     QPCADELKAR LGMPTTAATS ASAAAAAAAA THSAAAAAAA AAAAAAHLHT GTFLHPNLYQ
     NNAANSLRNI WNRSVGVPDN YYGNSGSSSG GGGGGVGGVN PGTPGAPSYL TTSYFNAPAA
     ASSQRSAAAN GFGTHQHHSL QHQQQQQQSY APQQQQQLSH HQQQQQQQQL HHQQQQQQQQ
     QQQQHSQSQL AAAQLASTHP HQLHSTPHDT HSTIANAAAA AAAAAAASVV SSSSGRSGAI
     SVAGSQSVIQ QPATSSVNYD LSYMLELGGF QQAKAKKPRK PKLEMGVKRA SREGSTTYLW
     EFLLKLLQDR EYCPRFIKWT NREKGVFKLV DSKAVSRLWG MHKNKPDMNY ETMGRALRYY
     YQRGILAKVD GQRLVYQFVD VPKDIVEIDC NGV