ID   E75_CHOFU               Reviewed;         690 AA.
AC   O01639;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Ecdysone-inducible protein E75;
DE   AltName: Full=Nuclear receptor subfamily 1 group D member 3;
GN   Name=E75; Synonyms=CHR75, NR1D3;
OS   Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Tortricoidea;
OC   Tortricidae; Tortricinae; Choristoneura.
OX   NCBI_TaxID=7141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9094210;
RX   DOI=10.1002/(sici)1520-6408(1997)20:1<36::aid-dvg5>3.0.co;2-a;
RA   Palli S.R., Ladd T.R., Ricci A.R., Sohi S.S., Retnakaran A.;
RT   "Cloning and development expression of Choristoneura hormone receptor 75: a
RT   homologue of the Drosophila E75A gene.";
RL   Dev. Genet. 20:36-46(1997).
CC   -!- FUNCTION: Orphan receptor possibly involved in the regulation of genes
CC       in the ecdysteroid cascade. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; U63930; AAB52717.1; -; mRNA.
DR   AlphaFoldDB; O01639; -.
DR   SMR; O01639; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001728; ThyrH_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   PRINTS; PR00546; THYROIDHORMR.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..690
FT                   /note="Ecdysone-inducible protein E75"
FT                   /id="PRO_0000053507"
FT   DOMAIN          154..401
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        44..120
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         47..67
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         84..108
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          411..434
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..516
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..690
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..428
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..497
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        573..598
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   690 AA;  76663 MW;  C8E22B5D11F39D23 CRC64;
     MTLVMSPDSS YGRYDAQPPV DGGMVNPVHR EREPELHIEF DGTTVLCRVC GDKASGFHYG
     VHSCEGCKGF FRRSIQQKIQ YRPCTKNQQC SILRINRNRC QYCRLKKCIA VGMSRDAVRF
     GRVPKREKAR ILAAMQQSSS SRAHEQAAAA ELDDAPRLLA RVVRAHLDTC EFTRDRVAAM
     RARARDCPTY SQPTLACPLN PAPELQSEKE FSQRFAHVIR GVIDFAGLIP GFQLLTQDDK
     FTLLKSGLFD ALFVRLICMF DAPLNSIICL NGQLMKRDSI QSGANARFLV DSTFKFAERM
     NSMNLTDAEI GLFCAIVLIT PDRPGLRNIE LVERMHARLK SCLQTVIAQN RADRPGFLRE
     LMDTLPDLRT LSTLHTEKLV VFRTEHKELL RQQMWGDEEV CPWADSGVDD SARSPLGSVS
     SSESGEAPSD CGTPLLAATL AGRRRLDSRG SVDEEALGVA HLAHNGLTVT PVRPPPRYRK
     LDSPTDSGIE SGNEKHERIV GPGSGCSSPR SSLEEHMEDR RPLAADDMPV LKRVLQAPPL
     YDASSLMDEA YKPHKKFRAM RRDTGEAEAR PMRPTPSPQP MHPHPGSPAH PAHPAHSPRP
     LRAPLSSTHS VLAKSLMEGP RMTPEQLKRT DIIQQYMRRG EAGEECRAGL LLYRGASPLQ
     VDVADAPQPL NLSKKSPSPP RSFMPPMLEA