ID   E75_METEN               Reviewed;         606 AA.
AC   O77245;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Nuclear hormone receptor E75;
DE   AltName: Full=Nuclear receptor subfamily 1 group D member 3;
GN   Name=E75; Synonyms=NR1D3;
OS   Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Metapenaeus.
OX   NCBI_TaxID=32278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pleopod;
RX   PubMed=9801156; DOI=10.1016/s0014-5793(98)01148-x;
RA   Chan S.-M.;
RT   "Cloning of a shrimp (Metapanaeus ensis) cDNA encoding a nuclear receptor
RT   superfamily member: an insect homologue of E75 gene.";
RL   FEBS Lett. 436:395-400(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- TISSUE SPECIFICITY: Expressed in the epidermis, eyestalk and the nerve
CC       cord of the pre-molt shrimp.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AF092946; AAC71770.1; -; mRNA.
DR   AlphaFoldDB; O77245; -.
DR   SMR; O77245; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..606
FT                   /note="Nuclear hormone receptor E75"
FT                   /id="PRO_0000053510"
FT   DOMAIN          138..392
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        29..105
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         32..52
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         69..93
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          382..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          546..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..413
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..495
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..563
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  67689 MW;  337A7FE74929438F CRC64;
     MFCDQDMYEI PADCQVLVDK TVIEFDGTTV LCRVCGDKAS GFHYGVHSCE GCKGFFRRSI
     QQKIQYRPCT KNQQCSILRI NRNRCQYCRL KKCIAVGMSR DAVRFGRVPK REKAKILAAM
     QSVNAKSQER AVLAELEDDT RVTAAIIRAH MDTCDFTRDK VAPMLQQART HPSYTQCPPY
     LACPLNPRPV PLHGQQELVQ DFSEALLPAI RGVVEFAKRL PGFQQLPQED QVTLLKAGVF
     EVLLVRLAGM FDARTNAMLC LNGQLVRREA LHTSVNARFL MDSMFDFAER VNSLALNDAE
     LALFCAVVVL APDRPGLRNA ELVERVHRRL VNCLQAVVSK HHPENPNLQR DLLSKIPDLR
     TLNTLHSEKL LKYKMTEHTA AGAPWDDSRS SWSMEQESSV GSPSSSYTTD EAMRSPVSCS
     ESICSGESAS SGESLCGSEV SGYTELRPPF PLARRRHDHS EGASSGDEAT ESPLKCPFSK
     RKSDSPDDSG IESGTDRSDK LSSPSVCSSP RSSIDEKERG GPARTICRCC ARLQRRPSST
     RICSWRKPTT SPIKSSVRNV GKRSLTPHSP PPPRSWSRRC LSLHSTRALW LRHTPPWPPV
     WRRPLA