ID   E7_VACCC                Reviewed;         166 AA.
AC   P68447; P21048;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Protein E7;
GN   ORFNames=E7R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
RN   [3]
RP   MYRISTOYLATION AT GLY-2, SUBCELLULAR LOCATION, AND MUTAGENESIS OF GLY-2.
RX   PubMed=9188589; DOI=10.1128/jvi.71.7.5218-5226.1997;
RA   Martin K.H., Grosenbach D.W., Franke C.A., Hruby D.E.;
RT   "Identification and analysis of three myristylated vaccinia virus late
RT   proteins.";
RL   J. Virol. 71:5218-5226(1997).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305|PubMed:9188589}.
CC   -!- PTM: Myristoylated. {ECO:0000269|PubMed:9188589}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae E7 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48045.1; -; Genomic_DNA.
DR   PIR; B42509; B42509.
DR   iPTMnet; P68447; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035345; E7R.
DR   Pfam; PF17467; E7R; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Lipoprotein; Myristate; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT   CHAIN           2..166
FT                   /note="Protein E7"
FT                   /id="PRO_0000099458"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000269|PubMed:9188589"
FT   MUTAGEN         2
FT                   /note="G->A: Complete loss of myristoylation."
FT                   /evidence="ECO:0000269|PubMed:9188589"
SQ   SEQUENCE   166 AA;  19512 MW;  0E527693710FD087 CRC64;
     MGTAATIQTP TKLMNKENAE MILEKIVDHI VMYISDESSD SENNPEYIDF RNRYEDYRSL
     IIKSDHEFVK LCKNHAEKSS PETQQMIIKH IYEQYLIPVS EVLLKPIMSM GDIITYNGCK
     DNEWMLEQLS TLNFNNLRTW NSCSIGNVTR LFYTFFSYLM KDKLNI