EAA3_CAEEL
ID EAA3_CAEEL Reviewed; 532 AA.
AC Q21353;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Putative sodium-dependent excitatory amino acid transporter glt-3;
GN Name=glt-3; ORFNames=K08F4.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-164 AND ASN-169, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR EMBL; Z68879; CAA93084.1; -; Genomic_DNA.
DR PIR; T23481; T23481.
DR RefSeq; NP_501844.1; NM_069443.5.
DR AlphaFoldDB; Q21353; -.
DR SMR; Q21353; -.
DR BioGRID; 42985; 2.
DR DIP; DIP-27068N; -.
DR STRING; 6239.K08F4.4; -.
DR TCDB; 2.A.23.2.9; the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.
DR iPTMnet; Q21353; -.
DR EPD; Q21353; -.
DR PaxDb; Q21353; -.
DR PeptideAtlas; Q21353; -.
DR EnsemblMetazoa; K08F4.4.1; K08F4.4.1; WBGene00001621.
DR GeneID; 177882; -.
DR KEGG; cel:CELE_K08F4.4; -.
DR UCSC; K08F4.4; c. elegans.
DR CTD; 177882; -.
DR WormBase; K08F4.4; CE06152; WBGene00001621; glt-3.
DR eggNOG; KOG3787; Eukaryota.
DR HOGENOM; CLU_019375_3_2_1; -.
DR InParanoid; Q21353; -.
DR OMA; AIIMRWI; -.
DR OrthoDB; 1184392at2759; -.
DR PhylomeDB; Q21353; -.
DR Reactome; R-CEL-210455; Astrocytic Glutamate-Glutamine Uptake And Metabolism.
DR Reactome; R-CEL-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-CEL-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR PRO; PR:Q21353; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00001621; Expressed in larva and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015501; F:glutamate:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015813; P:L-glutamate transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.3860.10; -; 1.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR Pfam; PF00375; SDF; 1.
DR SUPFAM; SSF118215; SSF118215; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..532
FT /note="Putative sodium-dependent excitatory amino acid
FT transporter glt-3"
FT /id="PRO_0000202075"
FT TOPO_DOM 1..5
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
SQ SEQUENCE 532 AA; 58470 MW; FA370EAD3796E5DF CRC64;
MGMKKDLLLV LTIESVVLGV VLGFVIRPFN PSNDTISLIG FPGEIFMQIV EMMILPLIMS
SVISALAQVR ARDARRIGIV TIIYYMITTF LATFTGIILV SSIHPGDPEL IHELGEGTLE
NTALSTLDTF LDQIRNMFPE NIIQATFQQV QTEYMPIKPS RVRNATSMNM TSEVLHKQTL
TYTNEMNVLG LIVFCSGFGI ILSILGDQAR LMINFFIVLD AIIMRWISAL MWCYPIGILS
LVCKNIIDID NLTETAQALA MYVVTVICGL MIHSLLTLPL LYFLVTKKSP FAFMTGMLQA
LATAFGTASS GATLPVTFRA LEENLKIDRR VTRFVLPLGA TITMDGTALY EAVAVIFIAQ
LHNIKLSLMD LVTISITTTV ASIGSGSVPA GLDTIVIVLT TVGLPAKDLS LLLTVDWLLD
RIRTSVNVLG DSFGAGIIHH LTRSSLLEAD TDELIRQIRE DIDILNNPHQ DTLPISHHSV
QSTIQNTQNA MQAPHVYSKS ARASFAPIPN EEERKALLKE SIALNKSDTH IV
