ADO1_ORYSJ
ID ADO1_ORYSJ Reviewed; 630 AA.
AC Q5Z8K3; Q0D9X1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Adagio-like protein 1;
GN OrderedLocusNames=Os06g0694000, LOC_Os06g47890;
GN ORFNames=OsJ_22473 {ECO:0000312|EMBL:EAZ38124.1}, P0550B04.22;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Component of an E3 ubiquitin ligase complex that plays a
CC central role in blue light-dependent circadian cycles. Acts as a blue
CC light photoreceptor, due to the presence of FMN, that mediates light-
CC regulated protein degradation of critical clock components by targeting
CC them to the proteasome complex (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: FMN binds covalently to cysteine after exposure to blue light and
CC is reversed in the dark. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ADAGIO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK111850; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AP003770; BAD53873.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF20352.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS99263.1; -; Genomic_DNA.
DR EMBL; CM000143; EAZ38124.1; -; Genomic_DNA.
DR EMBL; AK111850; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015643178.1; XM_015787692.1.
DR RefSeq; XP_015643179.1; XM_015787693.1.
DR AlphaFoldDB; Q5Z8K3; -.
DR SMR; Q5Z8K3; -.
DR STRING; 4530.OS06T0694000-01; -.
DR PaxDb; Q5Z8K3; -.
DR PRIDE; Q5Z8K3; -.
DR EnsemblPlants; Os06t0694000-01; Os06t0694000-01; Os06g0694000.
DR GeneID; 4341923; -.
DR Gramene; Os06t0694000-01; Os06t0694000-01; Os06g0694000.
DR KEGG; osa:4341923; -.
DR eggNOG; ENOG502QQR1; Eukaryota.
DR HOGENOM; CLU_033494_1_0_1; -.
DR InParanoid; Q5Z8K3; -.
DR OMA; VGDRNVC; -.
DR OrthoDB; 273755at2759; -.
DR PlantReactome; R-OSA-8933811; Circadian rhythm.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000007752; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR Genevisible; Q5Z8K3; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009637; P:response to blue light; IBA:GO_Central.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011498; Kelch_2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF55785; SSF55785; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50112; PAS; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Chromophore; Flavoprotein; FMN; Kelch repeat; Nucleus;
KW Photoreceptor protein; Receptor; Reference proteome; Repeat;
KW Sensory transduction; Ubl conjugation pathway.
FT CHAIN 1..630
FT /note="Adagio-like protein 1"
FT /id="PRO_0000247308"
FT DOMAIN 48..127
FT /note="PAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 216..262
FT /note="F-box"
FT REPEAT 378..428
FT /note="Kelch 1"
FT REPEAT 430..481
FT /note="Kelch 2"
FT REPEAT 483..535
FT /note="Kelch 3"
FT REPEAT 549..601
FT /note="Kelch 4"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="S-4a-FMN cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 630 AA; 67960 MW; 3A28F4ECE4D1628E CRC64;
MEWDSESDGA GSIGAGEEEE EEEEEEEGGF GGGGGGGGGG GGMFSFAIEG MLRASGPCGL
VVTDALEPDC PIIYVNCGFE EATGYRAEEV LGRNCRFLQC RGPFAQRRHP LVDAMVVSEI
RKCIDNGTEF RGDLLNFRKD GSPLMNKLHL TPIYGDDETI THYMGIQFFT NANVDLGPLP
GSLTKEPVRS TRFTPDNFFR PISTGPGQSN FCREYSSLFQ LTDEVLCQSI LSRLSPRDIA
SVSSVCRRLY LLTRNEDLWR MVCQNAWGSE TTRALETVPA AKRLGWGRLA RELTTLEAVA
WRKLTVGGAV EPSRCNFSAC AVGNRVVLFG GEGVNMQPMN DTFVLDLNAS NPEWRHVNVS
SAPPGRWGHT LSCLNGSLLV VFGGCGRQGL LNDVFTLDLD AKQPTWREIP GVAPPVPRSW
HSSCTLDGTK LVVSGGCADS GVLLSDTYLL DVTMDKPVWR EVPASWTPPS RLGHSMSVYG
GRKILMFGGL AKSGPLRLRS SDVFTMDLSE EEPCWRCLTG SGMPGAGNPA GAGPPPRLDH
VAVSLPGGRV LIFGGSVAGL HSASQLYLLD PTEEKPTWRI LNVPGRPPRF AWGHSTCVVG
GTKAIVLGGQ TGEEWMLTEI HELSLASSTV
