ID   EAA6_CAEEL              Reviewed;         542 AA.
AC   Q21751;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 3.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Putative sodium-dependent excitatory amino acid transporter glt-6;
GN   Name=glt-6; ORFNames=R05G6.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; FO081426; CCD71562.1; -; Genomic_DNA.
DR   PIR; T29354; T29354.
DR   RefSeq; NP_501210.3; NM_068809.7.
DR   AlphaFoldDB; Q21751; -.
DR   SMR; Q21751; -.
DR   STRING; 6239.R05G6.6; -.
DR   EPD; Q21751; -.
DR   PaxDb; Q21751; -.
DR   EnsemblMetazoa; R05G6.6.1; R05G6.6.1; WBGene00001624.
DR   GeneID; 187623; -.
DR   KEGG; cel:CELE_R05G6.6; -.
DR   UCSC; R05G6.6; c. elegans.
DR   CTD; 187623; -.
DR   WormBase; R05G6.6; CE41538; WBGene00001624; glt-6.
DR   eggNOG; KOG3787; Eukaryota.
DR   HOGENOM; CLU_019375_3_0_1; -.
DR   InParanoid; Q21751; -.
DR   OMA; YFAYQVG; -.
DR   OrthoDB; 1184392at2759; -.
DR   PhylomeDB; Q21751; -.
DR   Reactome; R-CEL-210455; Astrocytic Glutamate-Glutamine Uptake And Metabolism.
DR   Reactome; R-CEL-210500; Glutamate Neurotransmitter Release Cycle.
DR   Reactome; R-CEL-425393; Transport of inorganic cations/anions and amino acids/oligopeptides.
DR   PRO; PR:Q21751; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00001624; Expressed in larva and 3 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015501; F:glutamate:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015175; F:neutral amino acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015813; P:L-glutamate transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..542
FT                   /note="Putative sodium-dependent excitatory amino acid
FT                   transporter glt-6"
FT                   /id="PRO_0000202077"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        386..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          505..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   542 AA;  59156 MW;  70A66159E8BA9B41 CRC64;
     MKSKRRDDIV QFCRENTLLV MTMFSVFLGV VLGFGLRPLN LSQETLQLIN FPGEIFMQVL
     KMMILPLIFS SLISALAQMD AKESGQMGAS TVLYYLSTAV LATILGIFLV TVIHPGDPSI
     KGTDISEAPS DGNVSPLDTF LDLVRNMFPE NIIQATFERM QTTYVAIRPK IASKNGTSGN
     IIVKRSIGMT KGMNILGIIV FCTGFGIVIS QLGERARIVV DFFVILDAVI MRWVVTLMWF
     APLGITCLIC GNLLELDDIS DIASVLALYV FTVCAGLILH TIITVPLMYF FITRENPLPI
     FKGMIQAAVT AFGTASGGAT LPMSMQCLED HCGVDRRISR FVLPLGSTIN MDGNALYEAV
     AVIFIAQLNN VQLSLAEVLT VSITATIASI GLGSVPAGLV SILLILNTVG LPVRDVSMLF
     TVDWLLDRVR TAVNVLGDAF AASMVQHLLQ KKLDQADARH DYKTELKGEI ELLKSAATSR
     RPSFTMSEAS KELFLTHANT AGNSRIGSRI GSRRPSSTNL HLSWRNNNIE PPYTPLPNDE
     NV