ID   EAAT_ONCVO              Reviewed;         492 AA.
AC   Q25605;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Excitatory amino acid transporter;
DE   AltName: Full=Sodium-dependent glutamate/ aspartate transporter;
GN   Name=GLT-1;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8885221; DOI=10.1016/0166-6851(96)02667-9;
RA   Radice A.D., Lustigman S.;
RT   "Cloning and characterization of cDNAs encoding putative glutamate
RT   transporters from Caenorhabditis elegans and Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 80:41-53(1996).
CC   -!- FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential
CC       for terminating the postsynaptic action of glutamate by rapidly
CC       removing released glutamate from the synaptic cleft. Acts as a symport
CC       by cotransporting sodium (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC       (DAACS) (TC 2.A.23) family. {ECO:0000305}.
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DR   EMBL; U35251; AAB41937.1; -; mRNA.
DR   AlphaFoldDB; Q25605; -.
DR   SMR; Q25605; -.
DR   STRING; 6282.Q25605; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0098656; P:anion transmembrane transport; IEA:UniProt.
DR   GO; GO:1902475; P:L-alpha-amino acid transmembrane transport; IEA:UniProt.
DR   GO; GO:0015807; P:L-amino acid transport; IEA:UniProt.
DR   Gene3D; 1.10.3860.10; -; 1.
DR   InterPro; IPR001991; Na-dicarboxylate_symporter.
DR   InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR   InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR   Pfam; PF00375; SDF; 1.
DR   SUPFAM; SSF118215; SSF118215; 1.
DR   PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR   PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..492
FT                   /note="Excitatory amino acid transporter"
FT                   /id="PRO_0000202078"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  53391 MW;  CEE52D670F76A89E CRC64;
     MVSWIRKNLL LVLTVSSVVL GALCGFLLRG LQLSPQNIMY ISFPGELLMH MLKMMILPLI
     MSSLISGLAQ LDARQSGKLG SLAVTYYMFT TAVAVVTGIF LVLVIHPGDP TIKKEIGTGT
     EGKTVSTVDT LLDLLRNMFP ENVVQATFQQ VQTKYIKVRP KVVKNNDSAT LAALNNGSLD
     YVKASVEYTS GMNVLGVIVF CIAIGISLSQ LGQEAHVMVQ FFVIMDKVIM KLVMTVMWYS
     PFGILCLIMG KILEIHDLAD TARMLAMYMV TVLSGLAIHS LISLPLIFFV TTKKNPYVFM
     RGLFQAWITG LGTASSSDTL PITYICLEEN LGVDRRVTRF VLPVGATINM DGTALYEAVA
     AIFIAQINGV HLSFGQVVTV SLTATLASIG AASVPSAGLV TMLLVLTAVG LPVKDVSLIV
     AVDWLLDRIR TSINVLGDAM GAGIVYHYSK ADLDAHDRLA ATTRSHSIAM NDEKRQLAVY
     NSLPTDDEKH TH