ADO2_ORYSJ
ID ADO2_ORYSJ Reviewed; 635 AA.
AC Q67UX0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Putative adagio-like protein 2;
GN OrderedLocusNames=Os02g0150800, LOC_Os02g05700; ORFNames=OSJNBa0050G13.16;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
CC -!- FUNCTION: Component of an E3 ubiquitin ligase complex that plays a
CC central role in blue light-dependent circadian cycles. Acts as a blue
CC light photoreceptor, due to the presence of FMN, that mediates light-
CC regulated protein degradation of critical clock components by targeting
CC them to the proteasome complex (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: FMN binds covalently to cysteine after exposure to blue light and
CC is reversed in the dark. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ADAGIO family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP005412; BAD38049.1; -; Genomic_DNA.
DR EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q67UX0; -.
DR SMR; Q67UX0; -.
DR STRING; 4530.OS02T0150800-01; -.
DR PaxDb; Q67UX0; -.
DR PRIDE; Q67UX0; -.
DR eggNOG; ENOG502QQR1; Eukaryota.
DR InParanoid; Q67UX0; -.
DR PlantReactome; R-OSA-8933811; Circadian rhythm.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR Genevisible; Q67UX0; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009637; P:response to blue light; IBA:GO_Central.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR031118; Adagio-like_2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011498; Kelch_2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR46175:SF1; PTHR46175:SF1; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF55785; SSF55785; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Chromophore; Flavoprotein; FMN; Kelch repeat; Nucleus;
KW Photoreceptor protein; Receptor; Reference proteome; Repeat;
KW Sensory transduction; Ubl conjugation pathway.
FT CHAIN 1..635
FT /note="Putative adagio-like protein 2"
FT /id="PRO_0000247309"
FT DOMAIN 44..123
FT /note="PAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 209..255
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 371..421
FT /note="Kelch 1"
FT REPEAT 423..474
FT /note="Kelch 2"
FT REPEAT 476..530
FT /note="Kelch 3"
FT REPEAT 542..594
FT /note="Kelch 4"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 91
FT /note="S-4a-FMN cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 635 AA; 69221 MW; 1B5B8102838FAAF3 CRC64;
MEWDSDSEGS GDEEEEEEEE EEEGVEVGGG GDGGVGVGVG GGFALAIEGV LGACGLVVSD
ALEPDFPIIY VNRGFEDATG YRAEEVLGRN CRFLQCRGPF AKRRHPLVDT TVVTDIRRCL
EEGTVFQGDL LNFRKDGSPF MAKLQLTPIY GDDETITHYM GMQFFNDSNV DLGPLSVSTT
KEIVRSTLIT PDNTIRPSPM GKGFCSEHSD LFLLSDEVLC QKILSRLSPR DIASVNSVCK
RLYHLTRNDD LWRMVCQNAW GSEATQVLET VAGTRSLAWG RLARELTTLE AVTWRKLTVG
GAVEPSRCNF SACAAGNRVV LFGGEGVNMQ PMNDTFVLDL NASKPEWRHI NVRSAPPGRW
GHTLSCLNGS RLVLFGGCGR QGLLNDVFML DLDAQQPTWR EIPGLAPPVP RSWHSSCTLD
GTKLVVSGGC ADSGVLLSDT YLLDVTMERP VWREIPASWT PPCRLGHSLS VYDGRKILMF
GGLAKSGPLR LRSNDVFTLD LSENKPCWRC ITGSGMPGAS NPAGVGPPPR LDHVAVSLPG
GRILIFGGSV AGLHSASKLY LLDPTEEKPT WRILNVPGRP PRFAWGHSTC VVGGTKAIVL
GGQTGEEWTL TELHELSLMF PTLNQKDLEL YSWKL
