ID   EAEA_HAFAL              Reviewed;         280 AA.
AC   P52869;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Intimin;
DE   AltName: Full=Attaching and effacing protein;
DE   AltName: Full=Outer membrane protein;
DE   Flags: Fragment;
GN   Name=eaeA; Synonyms=eae;
OS   Hafnia alvei.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Hafnia.
OX   NCBI_TaxID=569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8168946; DOI=10.1128/iai.62.5.1835-1842.1994;
RA   Frankel G., Candy D.C.A., Everest P., Dougan G.;
RT   "Characterization of the C-terminal domains of intimin-like proteins of
RT   enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter
RT   freundii, and Hafnia alvei.";
RL   Infect. Immun. 62:1835-1842(1994).
CC   -!- FUNCTION: Necessary for the production of attaching and effacing
CC       lesions on tissue culture cells.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intimin/invasin family. {ECO:0000305}.
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DR   EMBL; L29509; AAA24937.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52869; -.
DR   SMR; P52869; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR003344; Big_1_dom.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013117; Intimin_C.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   Pfam; PF02369; Big_1; 1.
DR   Pfam; PF02368; Big_2; 1.
DR   Pfam; PF07979; Intimin_C; 1.
DR   SMART; SM00634; BID_1; 1.
DR   SMART; SM00635; BID_2; 1.
DR   SUPFAM; SSF49373; SSF49373; 2.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS51127; BIG1; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Transmembrane; Virulence.
FT   CHAIN           <1..280
FT                   /note="Intimin"
FT                   /id="PRO_0000211829"
FT   DOMAIN          1..92
FT                   /note="Big-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00445"
FT   DOMAIN          127..173
FT                   /note="BIG2"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   280 AA;  30146 MW;  C4DB4186477F673D CRC64;
     ITEIKADKTT AVANGKDAVT YTVKVMKDGK PLSGEEVTFT TTLGTLSKST EKTNTNGYRK
     VSLTSANQGK SLVSASVTMP QLMLKLLEVE FFTQLTIDNG NVEIVGTGAK GKLPNVWLQY
     GQVNLKANGG NGKYTWYSAN PAIASVDPSS GQVTLKDKGE TTITVVSGDK QTAIYTIAMP
     NSIVSVNSSG RVDYNTANNI CKNIKGSLPS SIKELKDLYD DWGAANKYQH YSQESITAWT
     LQTSENKVQG VASTYDLVRK NPLIDKVDIA GNYAYAVCVK