ADO3_ORYSJ
ID ADO3_ORYSJ Reviewed; 630 AA.
AC Q2R2W1; Q0IS84;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Adagio-like protein 3;
GN OrderedLocusNames=Os11g0547000, LOC_Os11g34460;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Component of an E3 ubiquitin ligase complex that plays a
CC central role in blue light-dependent circadian cycles. Acts as a blue
CC light photoreceptor, due to the presence of FMN, that mediates light-
CC regulated protein degradation of critical clock components by targeting
CC them to the proteasome complex. The SCF(ADO3) E3 ubiquitin ligase
CC complex is involved in the regulation of circadian clock-dependent
CC processes including transition to flowering time, hypocotyl elongation,
CC cotyledons and leaf movement rhythms (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- PTM: FMN binds covalently to cysteine after exposure to blue light and
CC is reversed in the dark. {ECO:0000250}.
CC -!- MISCELLANEOUS: 'Adagio' means slowly in Italian.
CC -!- SIMILARITY: Belongs to the ADAGIO family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DP000010; ABA94231.2; -; Genomic_DNA.
DR EMBL; AP008217; BAF28431.2; -; Genomic_DNA.
DR EMBL; AP014967; BAT14389.1; -; Genomic_DNA.
DR EMBL; AK100677; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015617056.1; XM_015761570.1.
DR AlphaFoldDB; Q2R2W1; -.
DR SMR; Q2R2W1; -.
DR STRING; 4530.OS11T0547000-01; -.
DR PaxDb; Q2R2W1; -.
DR PRIDE; Q2R2W1; -.
DR EnsemblPlants; Os11t0547000-01; Os11t0547000-01; Os11g0547000.
DR GeneID; 4350698; -.
DR Gramene; Os11t0547000-01; Os11t0547000-01; Os11g0547000.
DR KEGG; osa:4350698; -.
DR eggNOG; ENOG502QWBU; Eukaryota.
DR InParanoid; Q2R2W1; -.
DR OMA; AVCWRKF; -.
DR OrthoDB; 466221at2759; -.
DR PlantReactome; R-OSA-8933811; Circadian rhythm.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR ExpressionAtlas; Q2R2W1; baseline and differential.
DR Genevisible; Q2R2W1; OS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR GO; GO:2001007; P:negative regulation of cellulose biosynthetic process; IEA:EnsemblPlants.
DR GO; GO:0009911; P:positive regulation of flower development; IEA:EnsemblPlants.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:EnsemblPlants.
DR GO; GO:0009637; P:response to blue light; IBA:GO_Central.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 2.120.10.80; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR011498; Kelch_2.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR Pfam; PF00646; F-box; 1.
DR Pfam; PF07646; Kelch_2; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SUPFAM; SSF50965; SSF50965; 1.
DR SUPFAM; SSF55785; SSF55785; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50112; PAS; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Chromophore; Flavoprotein; FMN; Kelch repeat; Nucleus;
KW Photoreceptor protein; Receptor; Reference proteome; Repeat;
KW Sensory transduction; Ubl conjugation pathway.
FT CHAIN 1..630
FT /note="Adagio-like protein 3"
FT /id="PRO_0000247312"
FT DOMAIN 54..126
FT /note="PAS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 220..268
FT /note="F-box"
FT REPEAT 380..430
FT /note="Kelch 1"
FT REPEAT 432..483
FT /note="Kelch 2"
FT REPEAT 485..537
FT /note="Kelch 3"
FT REPEAT 545..597
FT /note="Kelch 4"
FT REPEAT 599..629
FT /note="Kelch 5"
FT MOD_RES 102
FT /note="S-4a-FMN cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 51
FT /note="L -> LA (in Ref. 5; AK100677)"
FT /evidence="ECO:0000305"
FT CONFLICT 68
FT /note="V -> A (in Ref. 5; AK100677)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="C -> W (in Ref. 5; AK100677)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="N -> S (in Ref. 5; AK100677)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 630 AA; 69580 MW; DEBA1FD19459F7A6 CRC64;
MFDAGDRGGG GGVVAVKRMK LCEEEEEEEE GMEVDEEEEE VGWVWRPPGG LAGEDEAAAW
EGRAAAIVVS DAVEVDFPVI YVNAAFEAAT GYRADEVLGR NCRFLQFRDP RAQRRHPLVD
PMVVSEIRRC LNEGIEFQGE LLNFRKDGAP LYNRLRLIPM HGDDGFVTHV IGIQLFSEAN
IDLSNVSYPV YKQQSNHRPN IQEINPASHE HIPKIQSSEY CCILQLSDEV LAHNILSRLS
PRDVASIGSV CTRMHELTKN DHLRKMVCQN AWGRDVTVRL EMSTKMLGWG RLARELTTLE
AASWRKFTVG GRVEPSRCNF SACAVGNRLV LFGGEGVNMQ PMDDTFVLNL ESAKPEWRRV
KVSASPPGRW GHTLSWLNGS WLVVFGGCGQ QGLLNDVFVL DLDAKQPTWR EVASEGPPLP
RSWHSSCTLD GSKLVVSGGC TESGVLLSDT FLLDLTKEKP AWKEIPTSWS PPSRLGHTLS
VFGKTKLFMF GGLAKSGSLR LRSCDAYTMD AGEDSPQWRQ LATTGFPSIG PPPRLDHVAV
SLPCGRIIIF GGSIAGLHSP SQLFLLDPAE EKPTWRILNV PGQPPKFAWG HSTCVVGGTR
VLVLGGHTGE EWILNELHEL CLASRPDEDE
