EAF2_CHICK
ID EAF2_CHICK Reviewed; 264 AA.
AC Q5ZHP7;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=ELL-associated factor 2;
GN Name=EAF2; ORFNames=RCJMB04_34m12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: May act as a transcriptional transactivator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q96CJ1}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000305}.
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DR EMBL; AJ721087; CAG32746.1; -; mRNA.
DR RefSeq; NP_001006525.1; NM_001006525.1.
DR AlphaFoldDB; Q5ZHP7; -.
DR SMR; Q5ZHP7; -.
DR STRING; 9031.ENSGALP00000032339; -.
DR PaxDb; Q5ZHP7; -.
DR Ensembl; ENSGALT00000032978; ENSGALP00000032339; ENSGALG00000011657.
DR GeneID; 424243; -.
DR KEGG; gga:424243; -.
DR CTD; 55840; -.
DR VEuPathDB; HostDB:geneid_424243; -.
DR eggNOG; KOG4795; Eukaryota.
DR GeneTree; ENSGT00390000017724; -.
DR InParanoid; Q5ZHP7; -.
DR OMA; TMSAMPQ; -.
DR OrthoDB; 1269479at2759; -.
DR PhylomeDB; Q5ZHP7; -.
DR PRO; PR:Q5ZHP7; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000011657; Expressed in spermatocyte and 13 other tissues.
DR ExpressionAtlas; Q5ZHP7; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:InterPro.
DR GO; GO:0008023; C:transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0003711; F:transcription elongation regulator activity; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; IBA:GO_Central.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; PTHR15970; 1.
DR Pfam; PF09816; EAF; 1.
PE 2: Evidence at transcript level;
KW Activator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..264
FT /note="ELL-associated factor 2"
FT /id="PRO_0000130340"
FT REGION 114..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29007 MW; 75A1537A21F0236E CRC64;
MNGMAPPLFE PKERVLQLGE TFEKQPRCAF HTVRYDFKPA SIDTACEGDL EVGKGEQVTI
TLPNIEGSTP PVTVFKGSKK PYLKECILII NHDTGECRLE KLSSNITVKK IRAEGSSKVQ
SRIEQQQQQI RNSSKTPNNI KNSPPKDKMF PSSPMDDIER ELKAEASIMD QLSSSDSSSD
SKSSSSSSSS SENSSSDSED EEARPSLPMS MPYLQPQPTL SAIPHQAVPD KDASHNRSQE
NSGHMMNTLR SDLQLSESGS DSDD
