位置:首页 > 蛋白库 > EAF2_RAT
EAF2_RAT
ID   EAF2_RAT                Reviewed;         262 AA.
AC   Q811X5;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=ELL-associated factor 2;
DE   AltName: Full=Testosterone-regulated apoptosis inducer and tumor suppressor protein;
GN   Name=Eaf2; Synonyms=Traits;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION IN APOPTOSIS.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12907652;
RA   Xiao W., Zhang Q., Jiang F., Pins M., Kozlowski J.M., Wang Z.;
RT   "Suppression of prostate tumor growth by U19, a novel testosterone-
RT   regulated apoptosis inducer.";
RL   Cancer Res. 63:4698-4704(2003).
CC   -!- FUNCTION: Acts as a transcriptional transactivator of ELL, ELL2 and
CC       TCEA1 elongation activities (By similarity). Potent inducer of
CC       apoptosis in prostatic and non-prostatic cell lines. {ECO:0000250,
CC       ECO:0000269|PubMed:12907652}.
CC   -!- SUBUNIT: Component of the super elongation complex (SEC), at least
CC       composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb
CC       complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL, ELL2 and TCEA1
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q96CJ1}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY049022; AAL12225.1; -; mRNA.
DR   RefSeq; NP_742044.1; NM_172047.1.
DR   AlphaFoldDB; Q811X5; -.
DR   SMR; Q811X5; -.
DR   STRING; 10116.ENSRNOP00000003208; -.
DR   CarbonylDB; Q811X5; -.
DR   PhosphoSitePlus; Q811X5; -.
DR   PaxDb; Q811X5; -.
DR   Ensembl; ENSRNOT00000003208; ENSRNOP00000003208; ENSRNOG00000002350.
DR   GeneID; 266787; -.
DR   KEGG; rno:266787; -.
DR   UCSC; RGD:628879; rat.
DR   CTD; 55840; -.
DR   RGD; 628879; Eaf2.
DR   eggNOG; KOG4795; Eukaryota.
DR   GeneTree; ENSGT00390000017724; -.
DR   HOGENOM; CLU_025755_1_0_1; -.
DR   InParanoid; Q811X5; -.
DR   OMA; TMSAMPQ; -.
DR   OrthoDB; 1269479at2759; -.
DR   PhylomeDB; Q811X5; -.
DR   TreeFam; TF320864; -.
DR   Reactome; R-RNO-112382; Formation of RNA Pol II elongation complex.
DR   Reactome; R-RNO-674695; RNA Polymerase II Pre-transcription Events.
DR   Reactome; R-RNO-75955; RNA Polymerase II Transcription Elongation.
DR   PRO; PR:Q811X5; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000002350; Expressed in spleen and 11 other tissues.
DR   Genevisible; Q811X5; RN.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:InterPro.
DR   GO; GO:0008023; C:transcription elongation factor complex; ISS:UniProtKB.
DR   GO; GO:0003711; F:transcription elongation regulator activity; ISO:RGD.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0060767; P:epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISO:RGD.
DR   GO; GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0034243; P:regulation of transcription elongation from RNA polymerase II promoter; ISO:RGD.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   1: Evidence at protein level;
KW   Activator; Apoptosis; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="ELL-associated factor 2"
FT                   /id="PRO_0000130339"
FT   REGION          17..104
FT                   /note="Necessary for interaction with ELL"
FT                   /evidence="ECO:0000250"
FT   REGION          124..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..262
FT                   /note="Necessary for transactivation activity"
FT                   /evidence="ECO:0000250"
FT   REGION          248..262
FT                   /note="Necessary for interaction with TCEA1 and
FT                   transactivation activity"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        124..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         146
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CJ1"
FT   MOD_RES         151
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CJ1"
FT   MOD_RES         154
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CJ1"
SQ   SEQUENCE   262 AA;  28933 MW;  FD34BA01DC8D26CC CRC64;
     MNGPAGLAYL DRRERILKLG ESFEKQPRCA FHTVRYDFKP ASVDASCEGN LEVGKGEQVT
     ITLPNIEGST PPVTVFKGSK RPYLKECILI INHDTGECRL EKLSSNITVK KTRGEGSSKI
     QCRLEQQQQQ MWNPPRTSNL VQHSPSEDKL SPTSLMDDIE RELKAEASLM DQMSSCDSSS
     DSRSSSSSSS EDSSSDSEDD DRSSPSGPRR YSSEHPSVSA GPQYRTSDAD TTCNRLYDNS
     ALLMSTLRSD LQLSESDSDS ED
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024