EAF3_ASHGO
ID EAF3_ASHGO Reviewed; 310 AA.
AC Q75AH9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Chromatin modification-related protein EAF3;
GN Name=EAF3; OrderedLocusNames=ADL052W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in deacetylation of histones, chromatin assembly and
CC chromosome segregation. May act as a transcriptional oscillator,
CC directing histone deacetylases to specific chromosomal domains.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC involved in DNA repair (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
CC -!- SIMILARITY: Belongs to the MRG family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS51868.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016817; AAS51868.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_984044.1; NM_209397.1.
DR AlphaFoldDB; Q75AH9; -.
DR SMR; Q75AH9; -.
DR STRING; 33169.AAS51868; -.
DR GeneID; 4620186; -.
DR KEGG; ago:AGOS_ADL052W; -.
DR eggNOG; KOG3001; Eukaryota.
DR InParanoid; Q75AH9; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0032221; C:Rpd3S/Clr6-CII complex; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016573; P:histone acetylation; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0043968; P:histone H2A acetylation; IBA:GO_Central.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.274.30; -; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR008676; MRG.
DR InterPro; IPR038217; MRG_C_sf.
DR InterPro; IPR026541; MRG_dom.
DR InterPro; IPR025995; Tudor-knot.
DR PANTHER; PTHR10880; PTHR10880; 1.
DR Pfam; PF05712; MRG; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR PIRSF; PIRSF038133; HAT_Nua4_EAF3/MRG15; 1.
DR SUPFAM; SSF54160; SSF54160; 1.
DR PROSITE; PS51640; MRG; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..310
FT /note="Chromatin modification-related protein EAF3"
FT /id="PRO_0000088772"
FT DOMAIN 8..80
FT /note="Tudor-knot"
FT /evidence="ECO:0000255"
FT DOMAIN 128..308
FT /note="MRG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00972"
FT REGION 104..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34437 MW; 186943AA8C2E8E8B CRC64;
MAFEIDGKCL CYHGPLLYEA RVLRVYDPAS QTYRDRTRTG VPLEEEDGLP AESRGREHWF
VHYQGWKSTW DEWVGQERIR PYNDENLALK RQLVQDAKAA AAAAKRAKAR PGKRERSPAP
AAPAAPAQGP RLAVRMPVEL KALLVDDWER ITKERKLVAL PCAPTVGDIL DAYYRERTAQ
LASPVAQTLL HEFVEGVHLY FDQCLSHLLL YRLERLQFDE ACGGAAPAAS GLPAPPEPRP
SAVYGGVHLL RLLSMMPELI CGTTMDEKSC HTVVAQCESL LAWMATHADD LVSGDYINTS
AQYEGVALGM
