ID   EAF3_DEBHA              Reviewed;         316 AA.
AC   Q6BT38;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Chromatin modification-related protein EAF3;
GN   Name=EAF3; OrderedLocusNames=DEHA2D03784g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in deacetylation of histones, chromatin assembly and
CC       chromosome segregation. May act as a transcriptional oscillator,
CC       directing histone deacetylases to specific chromosomal domains.
CC       Component of the NuA4 histone acetyltransferase complex which is
CC       involved in transcriptional activation of selected genes principally by
CC       acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also
CC       involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00972}.
CC   -!- SIMILARITY: Belongs to the MRG family. {ECO:0000305}.
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DR   EMBL; CR382136; CAG86770.1; -; Genomic_DNA.
DR   RefSeq; XP_458632.1; XM_458632.1.
DR   AlphaFoldDB; Q6BT38; -.
DR   SMR; Q6BT38; -.
DR   STRING; 4959.XP_458632.1; -.
DR   EnsemblFungi; CAG86770; CAG86770; DEHA2D03784g.
DR   GeneID; 2901436; -.
DR   KEGG; dha:DEHA2D03784g; -.
DR   VEuPathDB; FungiDB:DEHA2D03784g; -.
DR   eggNOG; KOG3001; Eukaryota.
DR   HOGENOM; CLU_039566_1_1_1; -.
DR   InParanoid; Q6BT38; -.
DR   OMA; GLQTYFD; -.
DR   OrthoDB; 1624495at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IEA:UniProt.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.274.30; -; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR008676; MRG.
DR   InterPro; IPR038217; MRG_C_sf.
DR   InterPro; IPR026541; MRG_dom.
DR   InterPro; IPR025995; Tudor-knot.
DR   PANTHER; PTHR10880; PTHR10880; 1.
DR   Pfam; PF05712; MRG; 1.
DR   Pfam; PF11717; Tudor-knot; 1.
DR   PIRSF; PIRSF038133; HAT_Nua4_EAF3/MRG15; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS51640; MRG; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..316
FT                   /note="Chromatin modification-related protein EAF3"
FT                   /id="PRO_0000088777"
FT   DOMAIN          13..84
FT                   /note="Tudor-knot"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          145..316
FT                   /note="MRG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00972"
FT   REGION          114..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  36163 MW;  AF7F763321D7B8C2 CRC64;
     MSGDDAAVFK PNARVLAYHG PLIYEAKVIK IHEKNKTFIE DGEGKHQPIE GGNLPEEYYS
     VNAYFVHYKG WKAKWDEWVG PDRILEYNEA NVQAQKELKE QLTKAKIKPK VKAEPAVAST
     GTKKRGMPVS SASTVTKKKK TDPNRVNEVS IFMKPELKYI LVDDWEFITK ERKIINIPSS
     RPVTVILNDY LQSKKDQDTS HQTMDVINEI MQGLELYFNK SLSLILLYKF ERLQYMNLLK
     EHGDDLRPSE LYGVEHLLRL FVALPGLIAQ TTMDSVSINV LVKQSKDILE FITDNMSVYL
     NDYVNVSPAY DSLARS