EAF5_ASHGO
ID EAF5_ASHGO Reviewed; 221 AA.
AC Q757R4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Chromatin modification-related protein EAF5;
GN Name=EAF5; OrderedLocusNames=AEL052W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EAF5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS52633.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE016818; AAS52633.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_984809.1; NM_210163.1.
DR AlphaFoldDB; Q757R4; -.
DR SMR; Q757R4; -.
DR STRING; 33169.AAS52633; -.
DR GeneID; 4621002; -.
DR KEGG; ago:AGOS_AEL052W; -.
DR eggNOG; ENOG502S0AH; Eukaryota.
DR InParanoid; Q757R4; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR InterPro; IPR026226; EAF5.
DR PRINTS; PR02067; PROTEINEAF5.
PE 3: Inferred from homology;
KW Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..221
FT /note="Chromatin modification-related protein EAF5"
FT /id="PRO_0000086889"
SQ SEQUENCE 221 AA; 25873 MW; E79754C7DCD6BFB7 CRC64;
MNISKVLILE TLYELLLNGQ TNRVSLVRLQ ADVNDHPMTK QLAHQWQTLK INDILDVIKL
LFPKQTSLSD GQIIFYNLQI VEIRDTLLDV VRECQDTLVK DVKQLEQQYQ AIKSHDDMKI
RRERIMGMYR DTILAKLQSF QHFHRLYSKL DPSPVVRDMM DLERIKATSI ENLSHLQHIL
QKCVTDSVMT TKAGSDRYRE IILSQGELDD TVKFVRYAMD N