ID   EAF5_CANGA              Reviewed;         205 AA.
AC   Q6FJV4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Chromatin modification-related protein EAF5;
GN   Name=EAF5; OrderedLocusNames=CAGL0M03289g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF5 family. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62466.1; -; Genomic_DNA.
DR   RefSeq; XP_449490.1; XM_449490.1.
DR   AlphaFoldDB; Q6FJV4; -.
DR   SMR; Q6FJV4; -.
DR   EnsemblFungi; CAG62466; CAG62466; CAGL0M03289g.
DR   GeneID; 2891498; -.
DR   KEGG; cgr:CAGL0M03289g; -.
DR   CGD; CAL0136813; CAGL0M03289g.
DR   VEuPathDB; FungiDB:CAGL0M03289g; -.
DR   HOGENOM; CLU_1337349_0_0_1; -.
DR   InParanoid; Q6FJV4; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:1990453; C:nucleosome disassembly/reassembly complex; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IEA:EnsemblFungi.
DR   GO; GO:0016573; P:histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0006337; P:nucleosome disassembly; IEA:EnsemblFungi.
DR   GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR026226; EAF5.
DR   PRINTS; PR02067; PROTEINEAF5.
PE   3: Inferred from homology;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Chromatin modification-related protein EAF5"
FT                   /id="PRO_0000086890"
SQ   SEQUENCE   205 AA;  23848 MW;  4FEDA591D0EB9AAF CRC64;
     MNEEIQTLLI YQICDSLRFQ ANMEDISVDD VMDVMQENIM VECLLDGVIM DKADVQKIVI
     QYVTDGELGE EAIGDKMESM YSNSRKKLLK EIDDLDNTIS TNRKKDKLLN LYRDTVLNRL
     QNKKTVLDKL YHGMKEDSSV IRNRIYLERI KNETPNSIAE LQLMLQRSIA DCIMSEPIGS
     EKYNIAKEIQ INLEDTIRFM KRALE