ID   EAF5_KLULA              Reviewed;         275 AA.
AC   Q6CX42;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Chromatin modification-related protein EAF5;
GN   Name=EAF5; OrderedLocusNames=KLLA0A11440g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF5 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH03085.1; -; Genomic_DNA.
DR   RefSeq; XP_451497.1; XM_451497.1.
DR   AlphaFoldDB; Q6CX42; -.
DR   STRING; 28985.XP_451497.1; -.
DR   EnsemblFungi; CAH03085; CAH03085; KLLA0_A11440g.
DR   GeneID; 2896743; -.
DR   KEGG; kla:KLLA0_A11440g; -.
DR   eggNOG; ENOG502S0AH; Eukaryota.
DR   HOGENOM; CLU_071344_0_0_1; -.
DR   InParanoid; Q6CX42; -.
DR   OMA; DFDDTVQ; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR026226; EAF5.
DR   PRINTS; PR02067; PROTEINEAF5.
PE   3: Inferred from homology;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..275
FT                   /note="Chromatin modification-related protein EAF5"
FT                   /id="PRO_0000086891"
FT   REGION          107..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  31149 MW;  701FAE20ACCB5750 CRC64;
     MFKEFLLLDV LYDELLNSQT NKVSLIRLRT GFNDHKIHKF TRMEDIKINE ILDMIKEMFP
     NQTSLNDGQI TFYHLQINEI QNKIMDVYER CQRDLVGKLA KNEKELKRGK VGKVSHTGSN
     GNKSNSSSSS SSTSAISNGA GAAGATTHSV LSTPAASTST TTNNSSKVDY MKSRRGKILA
     MYRDTVIAKL ESFEQFKEVF SSFEKVNHNE VIKMENDLKK LKTLHLNNLI DLQWNLQNCV
     TNGIMSMGHE DTNRVLLAQD ELDMTINFVR NAMDN