ID   EAF6_CANAL              Reviewed;         211 AA.
AC   Q59QC2; A0A1D8PEC4;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Chromatin modification-related protein EAF6;
GN   Name=EAF6; OrderedLocusNames=CAALFM_C108510WA;
GN   ORFNames=CaO19.396, CaO19.8026;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF6 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26489.1; -; Genomic_DNA.
DR   RefSeq; XP_711884.1; XM_706791.2.
DR   AlphaFoldDB; Q59QC2; -.
DR   SMR; Q59QC2; -.
DR   STRING; 237561.Q59QC2; -.
DR   PRIDE; Q59QC2; -.
DR   GeneID; 3646494; -.
DR   KEGG; cal:CAALFM_C108510WA; -.
DR   CGD; CAL0000192577; EAF6.
DR   VEuPathDB; FungiDB:C1_08510W_A; -.
DR   eggNOG; ENOG502SEZK; Eukaryota.
DR   HOGENOM; CLU_093901_0_0_1; -.
DR   InParanoid; Q59QC2; -.
DR   OMA; PMEQNRV; -.
DR   OrthoDB; 1629629at2759; -.
DR   PRO; PR:Q59QC2; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IDA:CGD.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043967; P:histone H4 acetylation; IC:CGD.
DR   InterPro; IPR015418; Eaf6.
DR   PANTHER; PTHR13476; PTHR13476; 1.
DR   Pfam; PF09340; NuA4; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..211
FT                   /note="Chromatin modification-related protein EAF6"
FT                   /id="PRO_0000086894"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          61..90
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  23209 MW;  B19719F39D03C0DC CRC64;
     MSTKDTNDVK PTSSKSNEIS SSGTATPKKT SSVPAKEDRK DTTKKDIANE RTSSSKSKDD
     SEKYVELKNK LIQQILKKQE LTRKLTTLED SIYQKEIDYF EESPLGNIVK GFENFSKTSG
     GGGANKRKIV YSEDDHIFSL SSVNYIKSLM KRQGHTSNGG SSKDDFDDYE DSVDPTTASA
     GSKANSIEKN ETPSGSSGTP SRKRKARVLE D