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EAF6_DANRE
ID   EAF6_DANRE              Reviewed;         192 AA.
AC   Q6AZD3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Chromatin modification-related protein MEAF6;
DE            Short=MYST/Esa1-associated factor 6;
DE   AltName: Full=Esa1-associated factor 6 homolog;
DE            Short=Protein EAF6 homolog;
GN   Name=meaf6; ORFNames=zgc:100869;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of select genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. This modification may
CC       both alter nucleosome - DNA interactions and promote interaction of the
CC       modified histones with other proteins which positively regulate
CC       transcription. Component of HBO1 complexes, which specifically mediate
CC       acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced
CC       activity toward histone H4. Component of the MOZ/MORF complex which has
CC       a histone H3 acetyltransferase activity (By similarity).
CC       {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       Component of the hbo1 complex. Component of the moz/morf complex (By
CC       similarity). {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9HAF1}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SIMILARITY: Belongs to the EAF6 family. {ECO:0000305}.
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DR   EMBL; BC078210; AAH78210.1; -; mRNA.
DR   RefSeq; NP_001003756.1; NM_001003756.1.
DR   AlphaFoldDB; Q6AZD3; -.
DR   SMR; Q6AZD3; -.
DR   STRING; 7955.ENSDARP00000100426; -.
DR   PaxDb; Q6AZD3; -.
DR   Ensembl; ENSDART00000159215; ENSDARP00000132726; ENSDARG00000101216.
DR   GeneID; 445300; -.
DR   KEGG; dre:445300; -.
DR   CTD; 64769; -.
DR   ZFIN; ZDB-GENE-040808-12; meaf6.
DR   eggNOG; KOG3856; Eukaryota.
DR   GeneTree; ENSGT00390000015257; -.
DR   InParanoid; Q6AZD3; -.
DR   OMA; HPSAMFD; -.
DR   PhylomeDB; Q6AZD3; -.
DR   TreeFam; TF324130; -.
DR   Reactome; R-DRE-3214847; HATs acetylate histones.
DR   Reactome; R-DRE-6804758; Regulation of TP53 Activity through Acetylation.
DR   PRO; PR:Q6AZD3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000101216; Expressed in mature ovarian follicle and 28 other tissues.
DR   ExpressionAtlas; Q6AZD3; baseline and differential.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0070776; C:MOZ/MORF histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
DR   GO; GO:0044154; P:histone H3-K14 acetylation; ISS:UniProtKB.
DR   GO; GO:0043983; P:histone H4-K12 acetylation; ISS:UniProtKB.
DR   GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR   GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR   InterPro; IPR015418; Eaf6.
DR   PANTHER; PTHR13476; PTHR13476; 1.
DR   Pfam; PF09340; NuA4; 1.
PE   2: Evidence at transcript level;
KW   Activator; Centromere; Chromatin regulator; Chromosome; Coiled coil;
KW   Kinetochore; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..192
FT                   /note="Chromatin modification-related protein MEAF6"
FT                   /id="PRO_0000272612"
FT   REGION          106..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          11..45
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        163..181
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   192 AA;  21838 MW;  579B0A588BD349F9 CRC64;
     MAMHAKATPP QIPDTRRELS ELVKRKQELA ETLVNLERQI YAFEGSYLED TQMYGNIIRG
     WDRYLTNQKN SNSKTDRRNR KFKEAERLFS KSSVTSVAAV CALGGIPDHM NEKREPGSGT
     ESDTSPDLQN QENEPSQEDT EEADGALQDL KPQKAASTSS GSHHSSHKKR KNKNRHRFDM
     KMNKKPRADY SA
 
 
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