ID   EAF6_KLULA              Reviewed;         115 AA.
AC   Q6CPA6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Chromatin modification-related protein EAF6;
GN   Name=EAF6; OrderedLocusNames=KLLA0E06303g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF6 family. {ECO:0000305}.
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DR   EMBL; CR382125; CAG99320.1; -; Genomic_DNA.
DR   RefSeq; XP_454233.1; XM_454233.1.
DR   AlphaFoldDB; Q6CPA6; -.
DR   SMR; Q6CPA6; -.
DR   STRING; 28985.XP_454233.1; -.
DR   EnsemblFungi; CAG99320; CAG99320; KLLA0_E06337g.
DR   GeneID; 2894485; -.
DR   KEGG; kla:KLLA0_E06337g; -.
DR   eggNOG; KOG3856; Eukaryota.
DR   HOGENOM; CLU_093901_2_1_1; -.
DR   InParanoid; Q6CPA6; -.
DR   OMA; FVKQQEG; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:1990467; C:NuA3a histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:1990468; C:NuA3b histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IEA:EnsemblFungi.
DR   InterPro; IPR015418; Eaf6.
DR   PANTHER; PTHR13476; PTHR13476; 1.
DR   Pfam; PF09340; NuA4; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..115
FT                   /note="Chromatin modification-related protein EAF6"
FT                   /id="PRO_0000086897"
FT   COILED          1..43
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   115 AA;  13269 MW;  56819A1F3D87C4B7 CRC64;
     MDEQKKEYEK LKKKLRDALV QKKQLEAKWN SLEQEVYDKE TEYLSQKPSS RMGNILLGFQ
     GFNKSSSAQQ ILSDHSHSSN AQPLDDNDRI FSLSSYLFAK QLAASNHQEQ TKSND