ID   EAF6_NEUCR              Reviewed;         187 AA.
AC   Q7SDW6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Chromatin modification-related protein eaf6;
GN   Name=eaf6; ORFNames=NCU03289;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF6 family. {ECO:0000305}.
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DR   EMBL; CM002236; EAA34979.2; -; Genomic_DNA.
DR   RefSeq; XP_964215.2; XM_959122.2.
DR   AlphaFoldDB; Q7SDW6; -.
DR   SMR; Q7SDW6; -.
DR   STRING; 5141.EFNCRP00000002854; -.
DR   PRIDE; Q7SDW6; -.
DR   EnsemblFungi; EAA34979; EAA34979; NCU03289.
DR   GeneID; 3880364; -.
DR   KEGG; ncr:NCU03289; -.
DR   VEuPathDB; FungiDB:NCU03289; -.
DR   HOGENOM; CLU_081048_1_0_1; -.
DR   InParanoid; Q7SDW6; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   InterPro; IPR015418; Eaf6.
DR   PANTHER; PTHR13476; PTHR13476; 1.
DR   Pfam; PF09340; NuA4; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Coiled coil; DNA damage; DNA repair; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..187
FT                   /note="Chromatin modification-related protein eaf6"
FT                   /id="PRO_0000086898"
FT   REGION          99..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..49
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        99..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   187 AA;  19901 MW;  0F088A3532D192AC CRC64;
     MMDNSGPKMG AADGAAGIPY YEKQRQHLKE LLNKKKLLEK RLLAQEESIY QKETEYLENT
     PAGNIITGFD NYTKGTANVA AQRRKTGLTD ANRVFSRSSI SYNPAAQQDS QTPASSAPAS
     HAPTPVSTSF NNKDGASSAP TPTSATAGKA NSKKKKAATS GGAGVEDSET DSRETKKART
     NFGAVRK