ID   EAF6_XENTR              Reviewed;         191 AA.
AC   Q68ER9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Chromatin modification-related protein MEAF6;
DE            Short=MYST/Esa1-associated factor 6;
DE   AltName: Full=Esa1-associated factor 6 homolog;
DE            Short=Protein EAF6 homolog;
GN   Name=meaf6;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of select genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. This modification may
CC       both alter nucleosome - DNA interactions and promote interaction of the
CC       modified histones with other proteins which positively regulate
CC       transcription. Component of HBO1 complexes, which specifically mediate
CC       acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced
CC       activity toward histone H4. Component of the MOZ/MORF complex which has
CC       a histone H3 acetyltransferase activity (By similarity).
CC       {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       Component of the hbo1 complex. Component of the moz/morf complex (By
CC       similarity). {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9HAF1}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9HAF1}.
CC   -!- SIMILARITY: Belongs to the EAF6 family. {ECO:0000305}.
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DR   EMBL; BC080132; AAH80132.1; -; mRNA.
DR   RefSeq; NP_001007868.1; NM_001007867.1.
DR   AlphaFoldDB; Q68ER9; -.
DR   SMR; Q68ER9; -.
DR   GeneID; 493254; -.
DR   KEGG; xtr:493254; -.
DR   CTD; 64769; -.
DR   Xenbase; XB-GENE-975403; meaf6.
DR   HOGENOM; CLU_092163_1_0_1; -.
DR   InParanoid; Q68ER9; -.
DR   OrthoDB; 1629629at2759; -.
DR   Reactome; R-XTR-3214847; HATs acetylate histones.
DR   Reactome; R-XTR-6804758; Regulation of TP53 Activity through Acetylation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0000123; C:histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0070776; C:MOZ/MORF histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
DR   GO; GO:0044154; P:histone H3-K14 acetylation; ISS:UniProtKB.
DR   GO; GO:0043983; P:histone H4-K12 acetylation; ISS:UniProtKB.
DR   GO; GO:0043981; P:histone H4-K5 acetylation; ISS:UniProtKB.
DR   GO; GO:0043982; P:histone H4-K8 acetylation; ISS:UniProtKB.
DR   InterPro; IPR015418; Eaf6.
DR   PANTHER; PTHR13476; PTHR13476; 1.
DR   Pfam; PF09340; NuA4; 1.
PE   2: Evidence at transcript level;
KW   Activator; Centromere; Chromatin regulator; Chromosome; Coiled coil;
KW   Kinetochore; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..191
FT                   /note="Chromatin modification-related protein MEAF6"
FT                   /id="PRO_0000272614"
FT   REGION          104..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          11..47
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        164..182
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  21615 MW;  555CBF1F4AD112C1 CRC64;
     MAMHNKATPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED TQMYGNIIRG
     WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV SALAGVQDQL IEKREPGSGT
     ESDNSPDFQN QENEPSQDDT EDLDGSLSGV KPQKAASSAN SGGHHSSHKK RKNKNRHRID
     LKLNKKPRSD Y