ID   EAF7_DEBHA              Reviewed;         323 AA.
AC   Q6BKL0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Chromatin modification-related protein EAF7;
GN   Name=EAF7; OrderedLocusNames=DEHA2F20966g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC       is involved in transcriptional activation of selected genes principally
CC       by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC       also involved in DNA repair (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EAF7 family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89650.2; -; Genomic_DNA.
DR   RefSeq; XP_461261.2; XM_461261.1.
DR   AlphaFoldDB; Q6BKL0; -.
DR   STRING; 4959.XP_461261.2; -.
DR   EnsemblFungi; CAG89650; CAG89650; DEHA2F20966g.
DR   GeneID; 2903076; -.
DR   KEGG; dha:DEHA2F20966g; -.
DR   VEuPathDB; FungiDB:DEHA2F20966g; -.
DR   eggNOG; KOG4051; Eukaryota.
DR   HOGENOM; CLU_860579_0_0_1; -.
DR   InParanoid; Q6BKL0; -.
DR   OMA; MRCILER; -.
DR   OrthoDB; 1476852at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0043189; C:H4/H2A histone acetyltransferase complex; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR012423; Eaf7/MRGBP.
DR   Pfam; PF07904; Eaf7; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..323
FT                   /note="Chromatin modification-related protein EAF7"
FT                   /id="PRO_0000215879"
FT   REGION          74..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..91
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..168
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..210
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..248
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..298
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   323 AA;  36406 MW;  00A8ED368DF927EC CRC64;
     MDEENDMREW SLDDEILLFD LMCDFKPAGH DKDKQMSIIV EKMNENVSEG TKPFSADDIW
     KKLGGMYDLE RVDELEDYID EDEDSAEEDG APNEKEEDKK EDIDQSSKDP DSSGLSDVET
     DMASEREELE VPKSGSRGNN KNKKDRVRKV DTKEDSTAVE TKDAEVTNEN EDANDDGDDN
     NEEEDEGNDE NEQEDPDDDD QDDDDDENES GEGSLQKRVT RGARKHQHEL SDQTGTPKPK
     KRTRSSAKLD AVETPPPSKR SQKTATPPAQ QTPTASAKRR KKSEVQESDA DKSNTRRSKR
     SLVPATTPSK PQAPPIRRSS RKK