ID   EAF_DROAN               Reviewed;         503 AA.
AC   B3MI72;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN   Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GF12230;
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217;
RN   [1] {ECO:0000312|EMBL:EDV35917.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV35917.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC       for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDV35917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH902619; EDV35917.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001959095.2; XM_001959059.2.
DR   RefSeq; XP_014763140.1; XM_014907654.1.
DR   RefSeq; XP_014763141.1; XM_014907655.1.
DR   AlphaFoldDB; B3MI72; -.
DR   SMR; B3MI72; -.
DR   STRING; 7217.FBpp0115422; -.
DR   EnsemblMetazoa; FBtr0382043; FBpp0342288; FBgn0089269.
DR   EnsemblMetazoa; FBtr0382251; FBpp0342478; FBgn0089269.
DR   EnsemblMetazoa; FBtr0385089; FBpp0345080; FBgn0089269.
DR   GeneID; 6495085; -.
DR   KEGG; dan:6495085; -.
DR   eggNOG; KOG4795; Eukaryota.
DR   InParanoid; B3MI72; -.
DR   OrthoDB; 1570404at2759; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..503
FT                   /note="Ell-associated factor Eaf"
FT                   /id="PRO_0000386598"
FT   REGION          143..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          251..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..161
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..212
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        251..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        297..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        369..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..457
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         199
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ   SEQUENCE   503 AA;  54751 MW;  0B7B8DC7A1B6FBC0 CRC64;
     MIMTKQKNTL AERLNIGDEV RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMASVDV
     GPNNQVTVIV PNSESSGVPH TVYKGNQREH AKECLMIYDK ETGAITIEKL NHNIQVKKTR
     SEISSKSSHL PPQNAAIMQG QVPGQQISNG SGPSTNVASG HGPGSGAKLE NSTMRITSKT
     KVSTGSRRNN IIDFKPRNSP MQQSSPSRPV AIHRSPQSAP AWDANNAQQT LPSIPMITDD
     DDFGLRAALH NGSQANTSGS STGSAVGHSD YGSASSSSHM GKQRQAPHHG HAKRQQRSSP
     PMVQQQPNFG RNSYNGGNNY AQQQQHEQQR PSPYGHGNSM PMDLDSSRDH ELTSKSVAHA
     AAVLEQQIGG ALSASSSSSE SDSSDSDSGS DSDDSTEDDR PSQQQQQHQH KAAQMHHQQQ
     QQQQHHLQQQ QQQQHFNQLP NLGLGSISPS YGNNHHQQQS RHHPHQQQQK QQSGIYASNG
     GFPNDLLQND LQLSSNSSDE DDD