EAF_DROER
ID EAF_DROER Reviewed; 508 AA.
AC B3NA01;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GG10755;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV59697.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV59697.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDV59697.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH954177; EDV59697.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001970638.2; XM_001970602.2.
DR AlphaFoldDB; B3NA01; -.
DR SMR; B3NA01; -.
DR STRING; 7220.FBpp0129301; -.
DR EnsemblMetazoa; FBtr0409958; FBpp0368409; FBgn0103060.
DR eggNOG; KOG4795; Eukaryota.
DR OrthoDB; 1570404at2759; -.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; PTHR15970; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Phosphoprotein; Transcription;
KW Transcription regulation.
FT CHAIN 1..508
FT /note="Ell-associated factor Eaf"
FT /id="PRO_0000386599"
FT REGION 140..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 200
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ SEQUENCE 508 AA; 55072 MW; 0319EB14C04C3BE0 CRC64;
MMMTKQKNSL AERLNIGEEV RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMASVDV
GSNNQVTVTV PNSESSGVPH TVYKGNQREY AKECLMIYDK ETGAITIEKL NHNIQVKKTR
NEVANKSVQL PGQNASVNMG QGQLHSQGAN GSVPGPISAP GHSTGTAPKM ENSTMRISTK
TKVSTGSRRN NIIDFKPRNS PMQQSSPSRA VPVHRSPQSA PAWDANNAQQ TLPSIPLITD
DDDFGLRAAL HNSGHANTSG SSTGSATGQP DFGSTSSSSH MGKQRQAPPH GHGKRQQMQQ
RLSPPMAQQQ QPSNYGRGYN GGHNHVQQQQ QRNSPQQQRP PAYGHGNSMP MDLDSTREHE
LTSQSVAQAA AALEQQIGGA LSASSSSSES DSSDSDSGSD SDDSTEDDRP TQGQQQDHQQ
QQQQQVYQNH NHQQQQIAQQ HLNQLPNLGL GSISPAYGSN HQHQQQMAPH QQQQKQQSGI
YASNGGFPND LLQNDLQLSS NSSDDDDE
