EAF_DROGR
ID EAF_DROGR Reviewed; 529 AA.
AC B4J6N6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GH20739;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1] {ECO:0000312|EMBL:EDW00939.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000312|EMBL:EDW00939.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR EMBL; CH916367; EDW00939.1; -; Genomic_DNA.
DR RefSeq; XP_001986072.1; XM_001986036.1.
DR AlphaFoldDB; B4J6N6; -.
DR SMR; B4J6N6; -.
DR STRING; 7222.FBpp0154645; -.
DR EnsemblMetazoa; FBtr0156153; FBpp0154645; FBgn0128202.
DR GeneID; 6559116; -.
DR KEGG; dgr:6559116; -.
DR eggNOG; KOG4795; Eukaryota.
DR HOGENOM; CLU_025755_2_1_1; -.
DR InParanoid; B4J6N6; -.
DR OMA; SIPMIMD; -.
DR OrthoDB; 1570404at2759; -.
DR PhylomeDB; B4J6N6; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; PTHR15970; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..529
FT /note="Ell-associated factor Eaf"
FT /id="PRO_0000386600"
FT REGION 155..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ SEQUENCE 529 AA; 58139 MW; 2B103E4EDD69BE25 CRC64;
MMMTKQKPTL TERLNLGDEV RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMATVDV
GSNNQVTVTV PNLESSGVPH TVYKGNHKKY TKECLIIYDK ETGVITLEKL NHNIQVKKTR
SEMTNKPSLM PAANAGPLMS GANGGGPIPS SMMAAAGSGS GTAPKLENST MRISSKTKVS
TGSRRNNIID FKPRNSPMQQ SSPSRPVVSH RSPQSAPAWH ANNAQQTLPS IPMITDDDDF
GLNAALHNGG GHANISGSST GSSSGQPDYV SSSHMGKQRQ ALPQGHAKRQ QMTQQRSSPP
MHHQQHQNQQ QQQQNYGRVG GSSNYAQQQH QQQMQQQQQQ HQQQQQRASF SHSNHSNSMP
LDINSPSHHD HVTQSVAQAA AVLEQQIGGE PSASSSSSES DSSDTDSGSD SDDSTDDDRP
TQQKQQNSAT HQQQHHQMQQ QHQQQQQHMH QLPNLGLGSI SPAYNSHYQH QQQQQQPPQQ
HSHHHHQQQQ QQQQQQQQSG IYASNGGFPN DLLQNDLQLS SNSSDDDDD
