ID   EAF_DROMO               Reviewed;         518 AA.
AC   B4KND9;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN   Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GI20822;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1] {ECO:0000312|EMBL:EDW09992.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW09992.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC       for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDW09992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH933808; EDW09992.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002006057.2; XM_002006021.2.
DR   AlphaFoldDB; B4KND9; -.
DR   SMR; B4KND9; -.
DR   STRING; 7230.FBpp0170039; -.
DR   EnsemblMetazoa; FBtr0425476; FBpp0383237; FBgn0143557.
DR   GeneID; 6580199; -.
DR   KEGG; dmo:Dmoj_GI20822; -.
DR   eggNOG; KOG4795; Eukaryota.
DR   InParanoid; B4KND9; -.
DR   OrthoDB; 1570404at2759; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..518
FT                   /note="Ell-associated factor Eaf"
FT                   /id="PRO_0000386601"
FT   REGION          119..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        251..377
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..511
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         192
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ   SEQUENCE   518 AA;  56617 MW;  B8B5094CC78C40F3 CRC64;
     MMMTKQKPTL TERLNIGGDE VRELKLGATF NPKNTATAFH TIKYDFKPAS VDTSRMATVD
     VGSNNQVTVT VPNLESSGVP QTVYKGNHKK YTKECLIIFD KETGAITLEK LNHNIQVKKT
     RSEMTNKPSL MPATNAAPMS SGPNGVPMPS GAMAGTGSGP KLENSTMRIT SKTKVSTGSR
     RNNIIDFKPR NSPMQQSSPS RPVASHRSPQ SAPAWHANNA QQTLPSIPMI MDDDDFGLSA
     ALHNGGGGGG GQANISGSST GSSVGQPDYG SVNMGKQRQA SSQGHAKRQQ QTQRSSPPMQ
     QQQQQQNYGR GGANNNYAQQ LHQQQQQQQQ QQLQQQQQQM QQRASFSHSN HSNSMPLDLD
     SPTHHEQAAQ SMAQAAAVLE QQIGGELSAS SSSSESESSD SDSGSDSDDS TEDDRSTHQQ
     QQPPGQLSQH HHHHMQQQQH MHQLPNLGLG SISPTYNSHQ HHQQQQQQHQ QQQQQQSHHH
     HHQQQQQQSS IYASNGGFPN DLLQNDLQLS SNSSDDDD