EAF_DROPE
ID EAF_DROPE Reviewed; 544 AA.
AC B4GCP2;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GL10937;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1] {ECO:0000312|EMBL:EDW31490.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR EMBL; CH479181; EDW31490.1; -; Genomic_DNA.
DR RefSeq; XP_002015600.1; XM_002015564.1.
DR AlphaFoldDB; B4GCP2; -.
DR SMR; B4GCP2; -.
DR STRING; 7234.FBpp0175044; -.
DR EnsemblMetazoa; FBtr0176552; FBpp0175044; FBgn0148547.
DR eggNOG; KOG4795; Eukaryota.
DR HOGENOM; CLU_025755_2_1_1; -.
DR OMA; SIPMIMD; -.
DR PhylomeDB; B4GCP2; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; PTHR15970; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..544
FT /note="Ell-associated factor Eaf"
FT /id="PRO_0000386602"
FT REGION 147..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 205
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ SEQUENCE 544 AA; 60037 MW; 900C144850E708C5 CRC64;
MMMTKQKNTL AERLNIGDEV RELKLGSTFN PKNTSTAFHT IKYDFKPASV DTSRMATVDV
GSNNQVTVIV PNSELALNVR LLIFGLTESS GVPHTVYKGN QREYAKECLM IYDKETGAIT
IEKLNHNIQV KKTRTEVTNK PVQLPAQSVP MNMGHQGQVL GTNGSVPPPM AQLAQGPLSG
PGGKLENSTM RVSSKDKVDF KPRNSPMQQS SPSRPVVTHR SPQSAPAWDA NNAQQTLPSI
PMITDDDDFG LRAAFHNGGQ ANISGSSTGS SSGQPDLYGS SSSSHMGKQR QAHGKRQQIH
QRSSPPVQQQ PHYQQQQQPN YGRAYNGASN YAQPHPQQQR HSPHQQPHQQ QHQRHSPQQQ
QQRHSPQQLQ QQRPTSYGHS NNMPMDLDSS REHDLASQSV AQAAAVLEQQ IGGALSASSS
SSESDSSDSD SGSDSDDSTE DDRSMKEQQE QQQQQQLQHQ QIQQPAPHHQ RHQQQQSQQH
MNQLPNLGLG SISPSYNNHH NHQQPQPQPQ QQQMSGVYAS NGGFPNDLLQ NDLQLSSNSS
DDDD
