ID   EAF_DROPS               Reviewed;         564 AA.
AC   B5E1I4;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN   Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GA24539;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EDY68749.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC       for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDY68749.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000071; EDY68749.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B5E1I4; -.
DR   SMR; B5E1I4; -.
DR   STRING; 7237.FBpp0277101; -.
DR   eggNOG; KOG4795; Eukaryota.
DR   InParanoid; B5E1I4; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..564
FT                   /note="Ell-associated factor Eaf"
FT                   /id="PRO_0000386603"
FT   REGION          179..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..564
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..441
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..557
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         215
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ   SEQUENCE   564 AA;  62340 MW;  B50F4D1E6BE6CFA0 CRC64;
     MMMTKQKNTL AERLNIGDEV RELKLGSTFN PKNTSTAFHT IKYDFKPASV DTSRMATVDV
     GSNNQVTVIV PNSELALNVR LLIFGLTESS GVPHTVYKGN QREYAKECLM IYDKETGAIT
     IEKLNHNIQV KKTRTEVTNK PVQLPAQSVP MNMGHQGQVL GTNGSVPPPM AQLAQGPLSG
     PGGKLENSTM RVSSKTKVST GSRRNNIIDF KPRNSPMQQS SPSRPVVTHR SPQSAPAWDA
     NNAQQTLPSI PMITDDDDFG LRAALHNGGQ ANISGSSTGS SSGQPDLYGS SSSSHMGKQR
     QAHGKRQQIH QRSSPPVQQQ PHYQQQQQPN YGRAYNGASN YAQQQQPQPQ QQRHSPHQQP
     HQQQHQRHSP QQQQQRHSPQ QLQQQRPTSY GHSNNMPMDL DSSREHDLAS QSVAQAAAVL
     EQQIGGALSA SSSSSESDSS DSDSGSDSDD STEDDRSMKE QQEQQQQQQL QHQQLQLQHQ
     QIQQPAPHHQ RHQQQQSQQH MNQLPNLGLG SISPSYNNHH NHQQPQPQPQ QQQMSGVYAS
     NGGFPNDLLQ NDLQLSSNSS DDDD