ID   EAF_DROSE               Reviewed;         503 AA.
AC   B4HQT6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN   Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GM20800;
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238;
RN   [1] {ECO:0000312|EMBL:EDW46746.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW46746.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC       for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR   EMBL; CH480816; EDW46746.1; -; Genomic_DNA.
DR   RefSeq; XP_002032733.1; XM_002032697.1.
DR   AlphaFoldDB; B4HQT6; -.
DR   SMR; B4HQT6; -.
DR   STRING; 7238.B4HQT6; -.
DR   EnsemblMetazoa; FBtr0203785; FBpp0202277; FBgn0175681.
DR   GeneID; 6607985; -.
DR   KEGG; dse:6607985; -.
DR   HOGENOM; CLU_025755_2_1_1; -.
DR   OMA; SIPMIMD; -.
DR   PhylomeDB; B4HQT6; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..503
FT                   /note="Ell-associated factor Eaf"
FT                   /id="PRO_0000386604"
FT   REGION          119..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        250..276
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         196
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ   SEQUENCE   503 AA;  54937 MW;  A7EEDFE830B0109F CRC64;
     MMMTKQKNSL AERLNIGEEA RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMASVDV
     GSNNQVTVTV PNSESSGVPH TVYKGNQREY AKECLMIYDK ETGAITIEKL NHNIQVKKTR
     NEVSNKSVQL PGQNMGQGQP HNQGANGAGP APTSVPGQGS GTAPKMENST MRISTKTKVS
     TGSRRNNIID FKPRNSPMQQ NSPSRPVPVH RSPQSAPAWD ANNAQQTLPS IPLITDDDDF
     GLRAALHNSG HANRSGSAAG QPDFVSTSSS THIGKQRQAP PHGHGKRQQM HQRLSPPMAQ
     QQQQHPSNYG RGYNGGHNHA QQQQQQQRNS PPRQRPSAYG HDNTMDVDSS REHELTSQSV
     AQAAAALEQQ IGGVLSASSS SSESDSSDSD SGSDSDDSTE DDRSTQGQQQ DHQQQPHQVY
     QNHNHTQQQV TQQHHNQLPN LGLGSISPAY GSNHQQQHQQ QMLQHQQKQK QQSGIYASNG
     GFPNDFLQND LQLSSNSSDD DDD