EAF_DROVI
ID EAF_DROVI Reviewed; 494 AA.
AC B4LMA2;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GJ20555;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1] {ECO:0000312|EMBL:EDW60980.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87 {ECO:0000312|EMBL:EDW60980.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR EMBL; CH940648; EDW60980.1; -; Genomic_DNA.
DR RefSeq; XP_002049787.1; XM_002049751.2.
DR AlphaFoldDB; B4LMA2; -.
DR SMR; B4LMA2; -.
DR STRING; 7244.FBpp0234972; -.
DR EnsemblMetazoa; FBtr0236480; FBpp0234972; FBgn0207695.
DR GeneID; 6625701; -.
DR KEGG; dvi:6625701; -.
DR eggNOG; KOG4795; Eukaryota.
DR HOGENOM; CLU_025755_2_1_1; -.
DR InParanoid; B4LMA2; -.
DR OMA; SIPMIMD; -.
DR OrthoDB; 1570404at2759; -.
DR PhylomeDB; B4LMA2; -.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR InterPro; IPR027093; EAF_fam.
DR InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR PANTHER; PTHR15970; PTHR15970; 1.
DR Pfam; PF09816; EAF; 1.
PE 3: Inferred from homology;
KW Activator; Developmental protein; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..494
FT /note="Ell-associated factor Eaf"
FT /id="PRO_0000386605"
FT REGION 119..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..456
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 188
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ SEQUENCE 494 AA; 54087 MW; 12C5BCD5A3A612CA CRC64;
MMMTKQKSTL TERLNIGGDE VRELKLGATF NPKNTSTAFH TIKYDFKPAS VDTSRMATVD
VGSNNQVTVT VPNLESSGVP QTVYKGNHKK YTKECLIIFD KETGAITLER LNHNIQVKKT
RSEVTNKPSL MSATNAPMSN GAPVPSSAAA GTGSAGKLEN STMRISSKTK VSTGSRRNNI
IDFKPRNSPM QQSSPSRPVA SHRSPQSAPA WHANNAQQTL PSIPMIMDDD DFGLSAALHN
GSQANISGSS TGSSAGQPDY ASVHSGKQRQ ATPQGHAKRQ QLTQRSSPPM QQQQHQNYGR
GSNNYAQQQQ QQQQQQLQQR ASFSHSNHSN SMPMDMDSPT HNEQTAQSMA QAAAALEQQI
GGELSASSSS SESDSSDSDS GSDSDDSTED DRPNHHTNQQ LPPAQQPQHH HMQHQQQQHM
HQLPNLELGS VSPAYNSHHH HQQQQQSHHH HHHQQQQQQQ HQQSGIYASN GGFPNDLLQN
DLQLSSNSSD DDDD
