ADP1_MYCGE
ID ADP1_MYCGE Reviewed; 1444 AA.
AC P20796; Q49286;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Adhesin P1;
DE AltName: Full=Attachment protein;
DE AltName: Full=Cytadhesin P1;
DE AltName: Full=MgPa;
DE Flags: Precursor;
GN Name=mgpA; OrderedLocusNames=MG191;
OS Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS (Mycoplasmoides genitalium).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=243273;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=2925238; DOI=10.1128/iai.57.4.1059-1065.1989;
RA Dallo S.F., Chavoya A., Su C.-J., Baseman J.B.;
RT "DNA and protein sequence homologies between the adhesins of Mycoplasma
RT genitalium and Mycoplasma pneumoniae.";
RL Infect. Immun. 57:1059-1065(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=2583522; DOI=10.1016/0378-1119(89)90051-6;
RA Inamine J.M., Loechel S., Collier A.M., Barile M.F., Hu P.-C.;
RT "Nucleotide sequence of the MgPa (mgp) operon of Mycoplasma genitalium and
RT comparison to the P1 (mpp) operon of Mycoplasma pneumoniae.";
RL Gene 82:259-267(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT "The minimal gene complement of Mycoplasma genitalium.";
RL Science 270:397-403(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-177.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A random sequencing approach for placing markers on the physical map of
RT Mycoplasma genitalium.";
RL Nucleic Acids Res. 19:6027-6031(1991).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 468-588; 627-723; 980-1162 AND
RP 1235-1289.
RC STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL J. Bacteriol. 175:7918-7930(1993).
CC -!- FUNCTION: The protein is the major adhesin mediating the attachment of
CC this mycoplasma to the ciliated epithelium.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the adhesin P1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M31431; AAA25420.1; -; Genomic_DNA.
DR EMBL; L43967; AAC71410.1; -; Genomic_DNA.
DR EMBL; X61522; CAA43734.1; -; Genomic_DNA.
DR EMBL; U02209; AAD12501.1; -; Genomic_DNA.
DR EMBL; U01694; AAB01007.1; -; Genomic_DNA.
DR EMBL; U01779; AAD10599.1; -; Genomic_DNA.
DR EMBL; U02159; AAD12441.1; -; Genomic_DNA.
DR PIR; A30588; A30588.
DR RefSeq; WP_010869366.1; NC_000908.2.
DR AlphaFoldDB; P20796; -.
DR SMR; P20796; -.
DR STRING; 243273.MG_191; -.
DR EnsemblBacteria; AAC71410; AAC71410; MG_191.
DR KEGG; mge:MG_191; -.
DR eggNOG; ENOG5030MWU; Bacteria.
DR HOGENOM; CLU_251889_0_0_14; -.
DR OMA; EYVPRMA; -.
DR OrthoDB; 1540677at2; -.
DR BioCyc; MGEN243273:G1GJ2-219-MON; -.
DR Proteomes; UP000000807; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020035; P:adhesion of symbiont to microvasculature; IEA:UniProtKB-KW.
DR InterPro; IPR022400; Adhesin_P1.
DR InterPro; IPR004940; Adhesin_P1_dom.
DR InterPro; IPR022116; P1_N.
DR Pfam; PF03257; Adhesin_P1; 1.
DR Pfam; PF12378; CytadhesinP1; 1.
DR TIGRFAMs; TIGR03839; termin_org_P1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytadherence; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..1444
FT /note="Adhesin P1"
FT /id="PRO_0000020628"
FT TRANSMEM 1353..1373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 231..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 927..949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1160..1161
FT /note="SQ -> FA (in Ref. 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1444 AA; 159651 MW; DB1DFF7A90FFF58A CRC64;
MHQPKKRLAK KSWAFLTAAL TLGVITGVGG YFLFNQNKQR SSVSNFAYQP KQLSVKHQQA
VDETLTPWTW NNNNFSSLKI TGENPGSFGL VRSQNDNLNI SSVTKNSSDD NLKYLNAVEK
YLDGQQNFAI RRYDNNGRAL YDINLAKMEN PSTVQRGLNG EPIFDPFKGF GLTGNAPTDW
NEIKGKVPVE VVQSPHSPNL YFVLLVPKVA LEYHNLNNQV VKESLEVKAT QSSFNPTQRL
QKDSPVKDSS KQGEKLSETT ASSMSSGMAT STRAKALKVE VERGSQSDSL LKNDFAKKPL
KHKNSSGEVK LEAEKEFTEA WKPLLTTDQI AREKGMGATV VSFYDAPYSE NHTAFGLVDH
IDPKKMVENY PPSWKTPKWN HHGIWDYNAR NLLLQTTGFF NPRRHPEWFD EGQAKADNTS
PGFKVGDTDH KKDGFKKNSS SPIALPFEAY FANIGNMVAI GNSVFIFGGN GHATKMFTTN
PLSIGVFRIK YTDNFSKSSV TGWPYAVLFG GLINPQTNGL KDLPLGTNRW FEYVPRMAVS
GVKWVGNQLV LAGTLTMGDT ATVPRLKYDQ LEKHLNLVAQ GQGLLREDLQ IFTPYGWANR
PDIPVGAWLQ DEMGSKFGPH YFLNNPDIQD NVNNDTVEAL ISSYKNTDKL KHVYPYRYSG
LYAWQLFNWS NKLTNTPLSA NFVNENSYAP NSLFAAILNE DLLTGLSDKI FYGKENEFAE
NEADRFNQLL SLNPNPNTNW ARYLNVVQRF TTGPNLDSST FDQFLDFLPW IGNGKPFSNS
PSPSTSASSS TPLPTFSNIN VGVKSMITQH LNKENTRWVF IPNFSPDIWT GAGYRVQSAN
QKNGIPFEQV KPSNNSTPFD PNSDDNKVTP SGGSSKPTTY PALPNSISPT SDWINALTFT
NKNNPQRNQL LLRSLLGTIP VLINKSGDSN DQFNKDSEQK WDKTETNEGN LPGFGEVNGL
YNAALLHTYG FFGTNTNSTD PKIGFKADSS SSSSSTLVGS GLNWTSQDVG NLVVINDTSF
GFQLGGWFIT FTDFIRPRTG YLGITLSSLQ DQTIIWADQP WTSFKGSYLD SDGTPKSLWD
PTALKSLPNS STTYDTNPTL SPSFQLYQPN KVKAYQTTNT YNKLIEPVDA TSAATNMTSL
LKLLTTKNIK AKLGKGTASS QGNNNGGGVS QTINTITTTG NISEGLKEET SIQAETLKKF
FDSKQNNKSE IGIGDSTFTK MDGKLTGVVS TPLVNLINGQ GATSDSDTEK ISFKPGNQID
FNRLFTLPVT ELFDPNTMFV YDQYVPLLVN LPSGFDQASI RLKVISYSVE NQTLGVRLEF
KDPQTQQFIP VLNASSTGPQ TVFQPFNQWA DYVLPLIVTV PIVVIILSVT LGLTIGIPMH
RNKKALQAGF DLSNKKVDVL TKAVGSVFKE IINRTGISNA PKKLKQATPT KPTPKTPPKP
PVKQ
