ID   EAF_DROYA               Reviewed;         501 AA.
AC   B4P1N5;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Ell-associated factor Eaf {ECO:0000250|UniProtKB:Q7JRJ1};
GN   Name=Eaf {ECO:0000250|UniProtKB:Q7JRJ1}; ORFNames=GE24070;
OS   Drosophila yakuba (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7245;
RN   [1] {ECO:0000312|EMBL:EDW89171.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tai18E2 / Tucson 14021-0261.01 {ECO:0000312|EMBL:EDW89171.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Promotes transcriptional elongation by Su(Tpl)/ELL. Essential
CC       for development (By similarity). {ECO:0000250|UniProtKB:Q7JRJ1}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96JC9}.
CC   -!- SIMILARITY: Belongs to the EAF family. {ECO:0000255}.
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DR   EMBL; CM000157; EDW89171.1; -; Genomic_DNA.
DR   RefSeq; XP_002089459.1; XM_002089423.2.
DR   AlphaFoldDB; B4P1N5; -.
DR   SMR; B4P1N5; -.
DR   STRING; 7245.FBpp0269080; -.
DR   PRIDE; B4P1N5; -.
DR   EnsemblMetazoa; FBtr0270588; FBpp0269080; FBgn0241209.
DR   GeneID; 6528413; -.
DR   KEGG; dya:Dyak_GE24070; -.
DR   eggNOG; KOG4795; Eukaryota.
DR   HOGENOM; CLU_025755_2_1_1; -.
DR   OMA; SIPMIMD; -.
DR   OrthoDB; 1570404at2759; -.
DR   PhylomeDB; B4P1N5; -.
DR   Proteomes; UP000002282; Chromosome 2L.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0032783; C:super elongation complex; IEA:EnsemblMetazoa.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0043620; P:regulation of DNA-templated transcription in response to stress; IEA:EnsemblMetazoa.
DR   InterPro; IPR027093; EAF_fam.
DR   InterPro; IPR019194; Tscrpt_elong_fac_Eaf_N.
DR   PANTHER; PTHR15970; PTHR15970; 1.
DR   Pfam; PF09816; EAF; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Nucleus; Phosphoprotein; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..501
FT                   /note="Ell-associated factor Eaf"
FT                   /id="PRO_0000386607"
FT   REGION          138..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..494
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7JRJ1"
SQ   SEQUENCE   501 AA;  54025 MW;  89B7D13C48C4B34A CRC64;
     MIMTKQKNSL AERLNIGEEV RELKLGATFN PKNTSTAFHT IKYDFKPASV DTSRMASVDV
     GSNNQVTVTV PNSESSGVPH TVYKGNQREY AKECLMIYDK ETGAITIEKL NHNIQVKKTR
     SEVTSKSVQL PGQHASVNMG QGQLHSQGAN GAGTGQGPIS APGHGSGTAP KMENSTMRIS
     TKTKVSTGSR RNNIIDFKPR NSPMQQSSPS RPVPVHRSPQ SAPAWDANNA QQTLPSIPLI
     TDDDDFGLRA ALHNSGHANT SGSSTGSATG QTDFGSISSS SHIGKQRQAP PHGHGKRQQM
     HQRQSPPMAQ QQQPSNYGRG YNGGQSHAQQ QRQRNSPQQQ RPPAYGHGNS MTMDLDSTRE
     QELTSQSVAQ AAAALEQQIG GALSASSSSS ESDSSDSDSG SDSDDSTEDD RPMEGQQPVY
     QNQNHQQQQM AQQHLNQLPN LGLGSISPAY GSNHQQQQQQ MVPHQQQQKQ QSGIYASNGG
     FPNDLLQNDL QLSSNSSDDD D