ID   EAGI_ENTAG              Reviewed;         216 AA.
AC   P33881;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein EagI;
GN   Name=eagI;
OS   Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea; Pantoea agglomerans group.
OX   NCBI_TaxID=549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7968529; DOI=10.1111/j.1365-2958.1993.tb00923.x;
RA   Swift S., Winson M.K., Chan P.F., Bainton N.J., Birdsall M., Reeves P.J.,
RA   Rees C.E.D., Chhabra S.R., Hill P.J., Throup J.P., Bycroft B.W.,
RA   Salmond G.P.C., Williams P., Stewart G.S.A.B.;
RT   "A novel strategy for the isolation of luxI homologues: evidence for the
RT   widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.";
RL   Mol. Microbiol. 10:511-520(1993).
CC   -!- FUNCTION: Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-
CC       homoserine lactone), an autoinducer molecule which binds to a yet
CC       uncharacterized transcriptional regulator.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; X74300; CAA52353.1; -; Genomic_DNA.
DR   PIR; S35945; S35945.
DR   PIR; S39625; S39625.
DR   AlphaFoldDB; P33881; -.
DR   SMR; P33881; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..216
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210882"
SQ   SEQUENCE   216 AA;  25282 MW;  0FB034E5355422CF CRC64;
     MLEIFDVSYN DLTERRSEDL YKLRKITFKD RLDWAVNCSN DMEFDEFDNS GTRYMLGIYD
     NQLVCSVRFI DLRLPNMITH TFQHLFGDVK LPEGDYIESS RFFVDKNRAK ALLGSRYPIS
     YVLFLSMINY ARHHGHTGIY TIVSRAMLTI AKRSGWEIEV IKEGFVSENE PIYLLRLPID
     CHNQHLLAKR IRDQSESNIA ALCQWPMSLT VTPEQV