ID   EAP_BOVIN               Reviewed;          64 AA.
AC   O02775; Q1RMP8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Enteric beta-defensin;
DE   Flags: Precursor;
GN   Name=EBD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9488394; DOI=10.1128/iai.66.3.1045-1056.1998;
RA   Tarver A.P., Clark D.P., Diamond G., Russell J.P., Erdjument-Bromage H.,
RA   Tempst P., Cohen K.S., Jones D.E., Sweeney R.W., Wines M., Hwang S.,
RA   Bevins C.L.;
RT   "Enteric beta-defensin: molecular cloning and characterization of a gene
RT   with inducible intestinal epithelial cell expression associated with
RT   Cryptosporidium parvum infection.";
RL   Infect. Immun. 66:1045-1056(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8589529; DOI=10.1007/bf00356177;
RA   Gallagher D.S. Jr., Ryan A.M., Diamond G., Bevins C.L., Womack J.E.;
RT   "Somatic cell mapping of beta-defensin genes to cattle syntenic group U25
RT   and fluorescence in situ localization to chromosome 27.";
RL   Mamm. Genome 6:554-556(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Inducibly expressed in enteric epithelial cells.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. LAP/TAP subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF000362; AAC48805.1; -; mRNA.
DR   EMBL; AF016539; AAC48804.1; -; Genomic_DNA.
DR   EMBL; BC114788; AAI14789.1; -; mRNA.
DR   RefSeq; NP_783634.1; NM_175703.3.
DR   AlphaFoldDB; O02775; -.
DR   SMR; O02775; -.
DR   STRING; 9913.ENSBTAP00000009756; -.
DR   PaxDb; O02775; -.
DR   Ensembl; ENSBTAT00000009756; ENSBTAP00000009756; ENSBTAG00000033545.
DR   GeneID; 281743; -.
DR   KEGG; bta:281743; -.
DR   CTD; 281743; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033545; -.
DR   eggNOG; ENOG502SYUI; Eukaryota.
DR   GeneTree; ENSGT00940000160995; -.
DR   HOGENOM; CLU_189296_4_1_1; -.
DR   InParanoid; O02775; -.
DR   OMA; EIGRCFF; -.
DR   OrthoDB; 1584343at2759; -.
DR   Reactome; R-BTA-1461957; Beta defensins.
DR   Reactome; R-BTA-1461973; Defensins.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000033545; Expressed in ascending colon and 84 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR006080; Defensin_beta/alpha.
DR   Pfam; PF00711; Defensin_beta; 1.
DR   SMART; SM00048; DEFSN; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         27..64
FT                   /note="Enteric beta-defensin"
FT                   /id="PRO_0000006967"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   64 AA;  7127 MW;  7E8642AE6F7A6068 CRC64;
     MRLHHLLLTL LFLVLSAGSG FTQGISNPLS CRLNRGICVP IRCPGNLRQI GTCFTPSVKC
     CRWR