ADPGK_BOVIN
ID ADPGK_BOVIN Reviewed; 497 AA.
AC A2VE47;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=ADP-dependent glucokinase;
DE Short=ADP-GK;
DE Short=ADPGK;
DE EC=2.7.1.147;
DE Flags: Precursor;
GN Name=ADPGK;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the phosphorylation of D-glucose to D-glucose 6-
CC phosphate using ADP as the phosphate donor. GDP and CDP can replace
CC ADP, but with reduced efficiency (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP + D-glucose = AMP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:11460, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:61548, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216;
CC EC=2.7.1.147;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU00584};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|PROSITE-
CC ProRule:PRU00584};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis. {ECO:0000255|PROSITE-
CC ProRule:PRU00584}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ADP-dependent glucokinase family.
CC {ECO:0000305}.
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DR EMBL; BC133568; AAI33569.1; -; mRNA.
DR RefSeq; NP_001075907.1; NM_001082438.2.
DR AlphaFoldDB; A2VE47; -.
DR SMR; A2VE47; -.
DR STRING; 9913.ENSBTAP00000002065; -.
DR PaxDb; A2VE47; -.
DR PRIDE; A2VE47; -.
DR Ensembl; ENSBTAT00000002065; ENSBTAP00000002065; ENSBTAG00000001578.
DR GeneID; 518158; -.
DR KEGG; bta:518158; -.
DR CTD; 83440; -.
DR VEuPathDB; HostDB:ENSBTAG00000001578; -.
DR VGNC; VGNC:25689; ADPGK.
DR eggNOG; KOG4184; Eukaryota.
DR GeneTree; ENSGT00390000017953; -.
DR HOGENOM; CLU_032362_0_0_1; -.
DR InParanoid; A2VE47; -.
DR OMA; MWRKASA; -.
DR OrthoDB; 1036373at2759; -.
DR TreeFam; TF313401; -.
DR Reactome; R-BTA-70171; Glycolysis.
DR UniPathway; UPA00109; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000001578; Expressed in diaphragm and 105 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043843; F:ADP-specific glucokinase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IBA:GO_Central.
DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR007666; ADP_PFK/GK.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR21208; PTHR21208; 1.
DR Pfam; PF04587; ADP_PFK_GK; 1.
DR SUPFAM; SSF53613; SSF53613; 1.
DR PROSITE; PS51255; ADPK; 1.
PE 2: Evidence at transcript level;
KW Glycolysis; Kinase; Magnesium; Metal-binding; Reference proteome; Secreted;
KW Signal; Transferase.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..497
FT /note="ADP-dependent glucokinase"
FT /id="PRO_0000346789"
FT DOMAIN 52..497
FT /note="ADPK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00584"
FT ACT_SITE 481
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00584"
FT BINDING 297
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00584"
FT BINDING 328
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00584"
FT BINDING 481
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00584"
SQ SEQUENCE 497 AA; 54086 MW; AFFC94E7DEB10179 CRC64;
MALWRGSAYA GFLALAVGCV FLLEPQLPGS ALRSLWSSLQ LGPAPAPPGV GSPEGRLAAA
WDALIVRPAR RWRRVAVGVN ACVDVVLSGV KLLQALGLSP GNGKDHSELH SRNDLEEAFV
HFMGKGAAAE RFFSDKETFH DIAQVASEFP EAQHYVGGNA ALIGQKFAAN SDLKVLLCGP
VGPKLHELLD DNVFVPPESL QEVDEFHLIL EYQAGEEWDQ LKAPHANRFI FSHDLSNGAM
NMLEVFVSSL EEFQPDLVVL SGLHMMEGQS KEFQRKRLLE VVTSISDIPT GVPVHLELAS
MTNKELMSTI VHQQVFPAVT SLGLNEQELL FLSQSASGPH SSLSSWNGVP DVGVVSDILF
WILKEHGKSE SRASDLSRIH FHTLAYHILA TVDGHWANQL AAVAAGARVA ATQACATETI
DTRRVSLKAP HEFMTSRLEA GSRVVLNPNE PVVEWHREGV SFHFTPVLVC KDPVRTVGLG
DAISAEGLFY SEVHPHL