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EAT17_CAEEL
ID   EAT17_CAEEL             Reviewed;         888 AA.
AC   S6F527; Q19101; S6EZL6; S6FMY8; S6FWN8; U4PBB2;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Rab GTPase-activating protein eat-17 {ECO:0000303|PubMed:23792950};
DE            Short=RabGAP eat-17 {ECO:0000303|PubMed:23792950};
DE   AltName: Full=Abnormal pharyngeal pumping eat-17 {ECO:0000305};
GN   Name=eat-17 {ECO:0000303|PubMed:23792950, ECO:0000312|WormBase:T24D11.1e};
GN   Synonyms=tbc-4 {ECO:0000312|WormBase:T24D11.1e};
GN   ORFNames=T24D11.1 {ECO:0000312|WormBase:T24D11.1e};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH RAB-6.2, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP   ARG-179 AND 266-GLN--HIS-888.
RX   PubMed=23792950; DOI=10.1534/genetics.113.152538;
RA   Straud S., Lee I., Song B., Avery L., You Y.J.;
RT   "The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder
RT   formation in Caenorhabditis elegans.";
RL   Genetics 195:115-125(2013).
CC   -!- FUNCTION: Rab GTPase activating protein for the small GTPase rab-6.2
CC       (PubMed:23792950). Required for grinder formation, which is the feeding
CC       organ that breaks down food (PubMed:23792950).
CC       {ECO:0000269|PubMed:23792950, ECO:0000303|PubMed:23792950}.
CC   -!- SUBUNIT: May interact with rab-6.2 (in GTP-bound form).
CC       {ECO:0000269|PubMed:23792950}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=e {ECO:0000312|WormBase:T24D11.1e};
CC         IsoId=S6F527-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:T24D11.1a};
CC         IsoId=S6F527-2; Sequence=VSP_061178, VSP_061179;
CC       Name=b {ECO:0000312|WormBase:T24D11.1b};
CC         IsoId=S6F527-3; Sequence=VSP_061179;
CC       Name=c {ECO:0000312|WormBase:T24D11.1c};
CC         IsoId=S6F527-4; Sequence=VSP_061176;
CC       Name=d {ECO:0000312|WormBase:T24D11.1d};
CC         IsoId=S6F527-5; Sequence=VSP_061177, VSP_061179;
CC       Name=f {ECO:0000312|WormBase:T24D11.1f};
CC         IsoId=S6F527-6; Sequence=VSP_061175;
CC   -!- TISSUE SPECIFICITY: Highly expressed in the terminal bulb muscles,
CC       pharyngeal muscle, in intestine and vulva.
CC       {ECO:0000269|PubMed:23792950}.
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DR   EMBL; BX284606; CCD68908.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDG24093.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDG24094.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDG24095.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDG24096.1; -; Genomic_DNA.
DR   EMBL; BX284606; CDH93027.1; -; Genomic_DNA.
DR   PIR; T29353; T29353.
DR   RefSeq; NP_001294784.1; NM_001307855.1.
DR   AlphaFoldDB; S6F527; -.
DR   SMR; S6F527; -.
DR   DIP; DIP-27429N; -.
DR   IntAct; S6F527; 3.
DR   STRING; 6239.T24D11.1e; -.
DR   EPD; S6F527; -.
DR   EnsemblMetazoa; T24D11.1a.1; T24D11.1a.1; WBGene00020770. [S6F527-2]
DR   EnsemblMetazoa; T24D11.1b.1; T24D11.1b.1; WBGene00020770. [S6F527-3]
DR   EnsemblMetazoa; T24D11.1c.1; T24D11.1c.1; WBGene00020770. [S6F527-4]
DR   EnsemblMetazoa; T24D11.1d.1; T24D11.1d.1; WBGene00020770. [S6F527-5]
DR   EnsemblMetazoa; T24D11.1e.1; T24D11.1e.1; WBGene00020770. [S6F527-1]
DR   EnsemblMetazoa; T24D11.1f.1; T24D11.1f.1; WBGene00020770. [S6F527-6]
DR   GeneID; 3565805; -.
DR   UCSC; F01G12.6; c. elegans.
DR   CTD; 3565805; -.
DR   WormBase; T24D11.1a; CE48459; WBGene00020770; eat-17. [S6F527-2]
DR   WormBase; T24D11.1b; CE48495; WBGene00020770; eat-17. [S6F527-3]
DR   WormBase; T24D11.1c; CE07015; WBGene00020770; eat-17. [S6F527-4]
DR   WormBase; T24D11.1d; CE48465; WBGene00020770; eat-17. [S6F527-5]
DR   WormBase; T24D11.1e; CE48484; WBGene00020770; eat-17. [S6F527-1]
DR   WormBase; T24D11.1f; CE48533; WBGene00020770; eat-17. [S6F527-6]
DR   eggNOG; KOG4436; Eukaryota.
DR   GeneTree; ENSGT00940000169844; -.
DR   HOGENOM; CLU_553888_0_0_1; -.
DR   OMA; GHIVADW; -.
DR   OrthoDB; 753960at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00020770; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; S6F527; baseline and differential.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:2000253; P:positive regulation of feeding behavior; IMP:UniProtKB.
DR   InterPro; IPR031214; Evi5.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   PANTHER; PTHR22957:SF254; PTHR22957:SF254; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; GTPase activation; Reference proteome.
FT   CHAIN           1..888
FT                   /note="Rab GTPase-activating protein eat-17"
FT                   /id="PRO_0000453575"
FT   DOMAIN          173..357
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          41..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          854..888
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          694..770
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        41..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..874
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..492
FT                   /note="Missing (in isoform f)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061175"
FT   VAR_SEQ         1..439
FT                   /note="MVPSPALVGTPSVFPHHQSTSFFQETASFFNLDWERLWHSRSNSNSTSSPRN
FT                   SPSQLSPPMAATAALRRSSDYGSADTECGEPCETGAPVSLNEVDLLAKMEQLNKSNEED
FT                   SRSVASKKTGSSESRKGAREHSPEEDEYFQEDLWSVWGELILNWEIEVKKRPNYIKDLV
FT                   KRGIPQHFRMIAWQNLSNASVSSVHDLYSDYMRQSSVYEKVIQRDIPRTYPELDFFKDG
FT                   ERGQSLLFNVIKAYSVHDKEVGYCQGSAFIVGLLLLQMPEEEAFAVLVSLMENYRLREL
FT                   YKPTMTDLGLCMFQLECLVQDQMPDLYTHFNNMGFDTSMYASSWFLTLFTTTMPLDIAN
FT                   RIMDCFLVEGMDFIFCISIAILQQARIELLRLDMEGMLKYFQREVRERYEFDADLLFTV
FT                   ANQVQLNAKRMKRLEKDYLTKRTKEQEEAVELR -> MRTRAQIGKQRFVWTKK (in
FT                   isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061176"
FT   VAR_SEQ         1..100
FT                   /note="Missing (in isoform d)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061177"
FT   VAR_SEQ         1..60
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061178"
FT   VAR_SEQ         139..141
FT                   /note="Missing (in isoform a, isoform b and isoform d)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_061179"
FT   MUTAGEN         179
FT                   /note="R->A: Grinder formation defects are rescued in 1.6%
FT                   of animals in an eat-17 ad707 mutant background."
FT                   /evidence="ECO:0000269|PubMed:23792950"
FT   MUTAGEN         179
FT                   /note="R->K: Grinder formation defects are rescued in 4.1%
FT                   of animals in an eat-17 ad707 mutant background."
FT                   /evidence="ECO:0000269|PubMed:23792950"
FT   MUTAGEN         266..888
FT                   /note="Missing: In ad707; defective grinder formation
FT                   characterized by disorganized cuticle ridges in the grinder
FT                   and the absence of grinder plates resulting in ineffective
FT                   grinding of bacteria."
FT                   /evidence="ECO:0000269|PubMed:23792950"
SQ   SEQUENCE   888 AA;  101803 MW;  C40B1D083A89B546 CRC64;
     MVPSPALVGT PSVFPHHQST SFFQETASFF NLDWERLWHS RSNSNSTSSP RNSPSQLSPP
     MAATAALRRS SDYGSADTEC GEPCETGAPV SLNEVDLLAK MEQLNKSNEE DSRSVASKKT
     GSSESRKGAR EHSPEEDEYF QEDLWSVWGE LILNWEIEVK KRPNYIKDLV KRGIPQHFRM
     IAWQNLSNAS VSSVHDLYSD YMRQSSVYEK VIQRDIPRTY PELDFFKDGE RGQSLLFNVI
     KAYSVHDKEV GYCQGSAFIV GLLLLQMPEE EAFAVLVSLM ENYRLRELYK PTMTDLGLCM
     FQLECLVQDQ MPDLYTHFNN MGFDTSMYAS SWFLTLFTTT MPLDIANRIM DCFLVEGMDF
     IFCISIAILQ QARIELLRLD MEGMLKYFQR EVRERYEFDA DLLFTVANQV QLNAKRMKRL
     EKDYLTKRTK EQEEAVELRR LRTENRLLRQ RIDYLEAESS ALADRLVKGQ VNLAQEAENY
     INIAHELNKL RDMNSDVHRK LEGAYETIRE LSSARRDNIM DTGTQVDDTS MIEHIHSLQQ
     ELIEAHTRQA DSENTLRDAK LRVSELEMAN KRLLENEPSE DVAGLQEELI SVKMREAESS
     LALKEMRQRL AELEQHWAKY VHVRAFDPSS ASIEKESTSE AHSTQQQPSP PLTSARARLA
     KITASLIGGS TEETDNCISV RELEDQLMGV RIKEADTLAE LKEMRQKVME LETQNHVCTN
     QLKRQDEEMK RVREDSEVLV KKRKELEDQL KDEKEKLDNK ESEFNEGRIN DRLKYSEAMQ
     TIQDLQSSIS QLELKKAEKW TQNQLRGSSV CDLDEESNSH GSICSNVDHL SLASDEMNAL
     LADMTVRIPT LDDLAEEGSA TETDELRPKE LNDGNDTTDS GVQLSDSH
 
 
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