ID   EAT5_CAEEL              Reviewed;         423 AA.
AC   Q27295;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Innexin eat-5;
DE   AltName: Full=Abnormal pharyngeal pumping eat-5;
GN   Name=eat-5; ORFNames=F13G3.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=8707836; DOI=10.1083/jcb.134.2.537;
RA   Starich T.A., Lee R.Y., Panzarella C., Avery L., Shaw J.E.;
RT   "eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans
RT   involved in cell-cell coupling.";
RL   J. Cell Biol. 134:537-548(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Structural component of the gap junctions (By similarity).
CC       Required for synchronized pharyngeal muscle contractions.
CC       {ECO:0000250|UniProtKB:O61715, ECO:0000269|PubMed:8707836}.
CC   -!- SUBUNIT: Heterooligomer of eat-5 and another innexin.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC       junction.
CC   -!- TISSUE SPECIFICITY: Expressed in pharyngeal muscles.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00351}.
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DR   EMBL; U59210; AAB09669.1; -; mRNA.
DR   EMBL; Z71259; CAA95793.1; -; Genomic_DNA.
DR   PIR; T20857; T20857.
DR   RefSeq; NP_492068.1; NM_059667.6.
DR   AlphaFoldDB; Q27295; -.
DR   SMR; Q27295; -.
DR   STRING; 6239.F13G3.8.2; -.
DR   PaxDb; Q27295; -.
DR   PeptideAtlas; Q27295; -.
DR   EnsemblMetazoa; F13G3.8.1; F13G3.8.1; WBGene00001136.
DR   GeneID; 172480; -.
DR   KEGG; cel:CELE_F13G3.8; -.
DR   UCSC; F13G3.8.1; c. elegans.
DR   CTD; 172480; -.
DR   WormBase; F13G3.8; CE05620; WBGene00001136; eat-5.
DR   eggNOG; ENOG502SID2; Eukaryota.
DR   HOGENOM; CLU_035763_0_2_1; -.
DR   InParanoid; Q27295; -.
DR   OMA; CFVYNTY; -.
DR   OrthoDB; 738314at2759; -.
DR   PhylomeDB; Q27295; -.
DR   PRO; PR:Q27295; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00001136; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005921; C:gap junction; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005243; F:gap junction channel activity; ISS:UniProtKB.
DR   GO; GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; PTHR11893; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Ion channel; Ion transport;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..423
FT                   /note="Innexin eat-5"
FT                   /id="PRO_0000208504"
FT   TRANSMEM        25..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
SQ   SEQUENCE   423 AA;  50326 MW;  AAB54EC85FCE472B CRC64;
     MNMLGSMFSM VKPRLDDLGT DRLNYYYSTL IIMGMSLTIT ARQYVGSPLQ CWVPAQFTKA
     WEQYAEDYCF VYNTYWVKPN DKVPLTVEER VSQQLIYYQW APFIMAIEAA FFYLPVIFWS
     MLSTKSGINI IKLVETAQKA EGAESEERKK QIDIICRHIS NNLRKRRNEE ETTKMAKIQR
     IFGMQHGKYI TNVYLVTKLI YMTNSFLQFY STNKFLGQND PYWGMRILDD ILKGTDWEHS
     GNFPRIAMCD FQVRVLGNLQ RYSIQCVLTL NMFNEKIFLF LYIWFLLVFF VTLFDSIFLC
     YNMFSSHKLV EFLQQFLDNQ DQDENDEKKP EERKVYRKEQ HSILLSEFCL HKFTPDIIIL
     LKMINNHTGD IVCTEIVGRM WNEFLERDAK LVLQRFVDND HHMETKSSSL KSEKLFEEQR
     SFI