EATX1_ENTFL
ID EATX1_ENTFL Reviewed; 90 AA.
AC Q9AL01;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Antitoxin epsilon 1;
OS Enterococcus faecalis (Streptococcus faecalis).
OG Plasmid pRE25.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1351;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RE25;
RX PubMed=11735367; DOI=10.1006/plas.2001.1544;
RA Schwarz F.V., Perreten V., Teuber M.;
RT "Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from
RT Enterococcus faecalis RE25.";
RL Plasmid 46:170-187(2001).
CC -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC Neutralizes the toxic effect of zeta toxin. Part of a postsegregational
CC killing (PSK) system involved in the killing of plasmid-free cells.
CC Continuous synthesis of the epsilon antitoxin is required to counteract
CC the zeta toxin (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: In the presence of the zeta toxin, forms an inactive
CC PezA(2)PezT(2) heterotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the epsilon antitoxin family. {ECO:0000305}.
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DR EMBL; X92945; CAC29204.1; -; Genomic_DNA.
DR RefSeq; WP_002331065.1; NZ_WYAD01000043.1.
DR RefSeq; YP_783933.1; NC_008445.1.
DR AlphaFoldDB; Q9AL01; -.
DR SMR; Q9AL01; -.
DR GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR GO; GO:0031342; P:negative regulation of cell killing; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:InterPro.
DR Gene3D; 1.10.8.130; -; 1.
DR InterPro; IPR035569; Antitoxin_epsilon/PezA_dom_sf.
DR InterPro; IPR015090; Epsilon_antitox.
DR Pfam; PF08998; Epsilon_antitox; 1.
DR SUPFAM; SSF81710; SSF81710; 1.
PE 3: Inferred from homology;
KW Plasmid; Toxin-antitoxin system.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..90
FT /note="Antitoxin epsilon 1"
FT /id="PRO_0000221546"
SQ SEQUENCE 90 AA; 10733 MW; 426243CFABCDFD47 CRC64;
MAVTYEKTFE IEIINELSAS VYNRVLNYVL NHELDTKNTR LLEVNLLNQL EVAQEVDLFQ
QPFEELQAIH EYWRSMNQYS KQILNKEKVA