ID   EATX2_ENTFL             Reviewed;          90 AA.
AC   Q9AL19;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Antitoxin epsilon 2;
OS   Enterococcus faecalis (Streptococcus faecalis).
OG   Plasmid pRE25.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RE25;
RX   PubMed=11735367; DOI=10.1006/plas.2001.1544;
RA   Schwarz F.V., Perreten V., Teuber M.;
RT   "Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from
RT   Enterococcus faecalis RE25.";
RL   Plasmid 46:170-187(2001).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the toxic effect of zeta toxin. Part of a postsegregational
CC       killing (PSK) system involved in the killing of plasmid-free cells.
CC       Continuous synthesis of the epsilon antitoxin is required to counteract
CC       the zeta toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: In the presence of the zeta toxin, forms an inactive
CC       PezA(2)PezT(2) heterotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the epsilon antitoxin family. {ECO:0000305}.
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DR   EMBL; X92945; CAC29173.1; -; Genomic_DNA.
DR   RefSeq; WP_002326825.1; NZ_WVTT01000003.1.
DR   RefSeq; YP_004033017.1; NC_014726.1.
DR   RefSeq; YP_783902.1; NC_008445.1.
DR   AlphaFoldDB; Q9AL19; -.
DR   SMR; Q9AL19; -.
DR   GeneID; 60887325; -.
DR   GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR   GO; GO:0031342; P:negative regulation of cell killing; IEA:InterPro.
DR   GO; GO:0009636; P:response to toxic substance; IEA:InterPro.
DR   Gene3D; 1.10.8.130; -; 1.
DR   InterPro; IPR035569; Antitoxin_epsilon/PezA_dom_sf.
DR   InterPro; IPR015090; Epsilon_antitox.
DR   Pfam; PF08998; Epsilon_antitox; 1.
DR   SUPFAM; SSF81710; SSF81710; 1.
PE   3: Inferred from homology;
KW   Plasmid; Toxin-antitoxin system.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..90
FT                   /note="Antitoxin epsilon 2"
FT                   /id="PRO_0000221547"
SQ   SEQUENCE   90 AA;  10720 MW;  426243CFABD81D47 CRC64;
     MAVTYEKTFE IEIINELSAS VYNRVLNYVL NHELDTKNTR LLEVNLLNQL EVAQEVDLFQ
     QPFEELQAIH EYWRSMNQYS KQILTKEKVA