ID   EATX_LACLL              Reviewed;          87 AA.
AC   Q93NB3;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Antitoxin epsilon;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OG   Plasmid pCRL291.1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Saavedra L., Fontana C., Vignolo G., Ruiz-Holgado A.P., Sesma F.;
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the toxic effect of cognate zeta toxin. Part of a
CC       postsegregational killing (PSK) system involved in the killing of
CC       plasmid-free cells. Continuous synthesis of the epsilon antitoxin is
CC       required to counteract the zeta toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: In the presence of the zeta toxin, forms an inactive
CC       PezA(2)PezT(2) heterotetramer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the epsilon antitoxin family. {ECO:0000305}.
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DR   EMBL; AF380336; AAK59285.1; -; Genomic_DNA.
DR   RefSeq; NP_116737.1; NC_002799.1.
DR   AlphaFoldDB; Q93NB3; -.
DR   SMR; Q93NB3; -.
DR   GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR   GO; GO:0031342; P:negative regulation of cell killing; IEA:InterPro.
DR   GO; GO:0009636; P:response to toxic substance; IEA:InterPro.
DR   Gene3D; 1.10.8.130; -; 1.
DR   InterPro; IPR035569; Antitoxin_epsilon/PezA_dom_sf.
DR   InterPro; IPR015090; Epsilon_antitox.
DR   Pfam; PF08998; Epsilon_antitox; 1.
DR   SUPFAM; SSF81710; SSF81710; 1.
PE   3: Inferred from homology;
KW   Plasmid; Toxin-antitoxin system.
FT   CHAIN           1..87
FT                   /note="Antitoxin epsilon"
FT                   /id="PRO_0000221548"
SQ   SEQUENCE   87 AA;  10278 MW;  59ABCABD8AD6AF14 CRC64;
     MALDYRKTFE IEIINEFQSA IHSKMLNYVL NNELDKSDST NLQTNLLNQL SNMNQINLFK
     LSLEELEAYH EYLRSIKKYA DSITRTT