EATX_STRAG
ID EATX_STRAG Reviewed; 90 AA.
AC Q936E0;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Antitoxin epsilon;
OS Streptococcus agalactiae.
OG Plasmid pIP501.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1311;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Thompson J.K., Collins M.A., Foley S.;
RT "Lactobacillus helveticus ATCC15009 as a host for native and conjugative
RT plasmid DNA.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC Neutralizes the toxic effect of cognate zeta toxin. Part of a
CC postsegregational killing (PSK) system involved in the killing of
CC plasmid-free cells. Continuous synthesis of the epsilon antitoxin is
CC required to counteract the zeta toxin (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: In the presence of the zeta toxin, forms an inactive
CC PezA(2)PezT(2) heterotetramer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the epsilon antitoxin family. {ECO:0000305}.
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DR EMBL; AJ301605; CAC70736.1; -; Genomic_DNA.
DR AlphaFoldDB; Q936E0; -.
DR SMR; Q936E0; -.
DR GO; GO:0015643; F:toxic substance binding; IEA:InterPro.
DR GO; GO:0031342; P:negative regulation of cell killing; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:InterPro.
DR Gene3D; 1.10.8.130; -; 1.
DR InterPro; IPR035569; Antitoxin_epsilon/PezA_dom_sf.
DR InterPro; IPR015090; Epsilon_antitox.
DR Pfam; PF08998; Epsilon_antitox; 1.
DR SUPFAM; SSF81710; SSF81710; 1.
PE 3: Inferred from homology;
KW Plasmid; Toxin-antitoxin system.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..90
FT /note="Antitoxin epsilon"
FT /id="PRO_0000221549"
SQ SEQUENCE 90 AA; 10778 MW; F37646DEBFD81D41 CRC64;
MAVTYEKTFE IEIINELSES VYNRVLNYVL NHELDTKNTR LLEVNLLNQL EVAQEVDLFQ
QPFEELQAIH EYWRSMNQYS KQILTKEKVA