EBHA_STAA1
ID EBHA_STAA1 Reviewed; 6713 AA.
AC A7X2C3;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Extracellular matrix-binding protein EbhA;
DE AltName: Full=ECM-binding protein homolog A;
GN Name=ebhA; OrderedLocusNames=SAHV_1422;
OS Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=418127;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu3 / ATCC 700698;
RX PubMed=17954695; DOI=10.1128/aac.00534-07;
RA Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT "Mutated response regulator graR is responsible for phenotypic conversion
RT of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT resistance to vancomycin-intermediate resistance.";
RL Antimicrob. Agents Chemother. 52:45-53(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- CAUTION: In strains Mu3, Mu50, N315 and Newman, ebh is divided into two
CC ORFs, ebhA and ebhB, which correspond to the C-terminal and N-terminal
CC parts of the full gene, respectively. {ECO:0000305}.
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DR EMBL; AP009324; BAF78305.1; -; Genomic_DNA.
DR SMR; A7X2C3; -.
DR KEGG; saw:SAHV_1422; -.
DR HOGENOM; CLU_000041_0_0_9; -.
DR OMA; GNWSIDL; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR011439; DUF1542.
DR InterPro; IPR020840; Extracell_matrix-bd_GA.
DR InterPro; IPR002988; GA_module.
DR InterPro; IPR009063; Ig/albumin-bd_sf.
DR Pfam; PF07564; DUF1542; 8.
DR Pfam; PF01468; GA; 19.
DR SMART; SM00844; GA; 46.
DR SUPFAM; SSF46997; SSF46997; 91.
PE 4: Predicted;
KW Cell membrane; Membrane; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..6713
FT /note="Extracellular matrix-binding protein EbhA"
FT /id="PRO_0000345969"
FT TRANSMEM 6518..6540
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..58
FT /note="FIVAR 1"
FT DOMAIN 126..184
FT /note="FIVAR 2"
FT DOMAIN 252..310
FT /note="FIVAR 3"
FT DOMAIN 378..436
FT /note="FIVAR 4"
FT DOMAIN 504..562
FT /note="FIVAR 5"
FT DOMAIN 630..688
FT /note="FIVAR 6"
FT DOMAIN 756..814
FT /note="FIVAR 7"
FT DOMAIN 882..940
FT /note="FIVAR 8"
FT DOMAIN 1008..1066
FT /note="FIVAR 9"
FT DOMAIN 1134..1192
FT /note="FIVAR 10"
FT DOMAIN 1260..1318
FT /note="FIVAR 11"
FT DOMAIN 1386..1444
FT /note="FIVAR 12"
FT DOMAIN 1512..1570
FT /note="FIVAR 13"
FT DOMAIN 1638..1696
FT /note="FIVAR 14"
FT DOMAIN 1764..1822
FT /note="FIVAR 15"
FT DOMAIN 1890..1948
FT /note="FIVAR 16"
FT DOMAIN 2142..2200
FT /note="FIVAR 17"
FT DOMAIN 2268..2325
FT /note="FIVAR 18"
FT DOMAIN 2393..2451
FT /note="FIVAR 19"
FT DOMAIN 2519..2577
FT /note="FIVAR 20"
FT DOMAIN 2645..2703
FT /note="FIVAR 21"
FT DOMAIN 2771..2829
FT /note="FIVAR 22"
FT DOMAIN 2897..2955
FT /note="FIVAR 23"
FT DOMAIN 3023..3081
FT /note="FIVAR 24"
FT DOMAIN 3149..3207
FT /note="FIVAR 25"
FT DOMAIN 3275..3333
FT /note="FIVAR 26"
FT DOMAIN 3401..3459
FT /note="FIVAR 27"
FT DOMAIN 3527..3585
FT /note="FIVAR 28"
FT DOMAIN 3653..3711
FT /note="FIVAR 29"
FT DOMAIN 3779..3837
FT /note="FIVAR 30"
FT DOMAIN 3905..3963
FT /note="FIVAR 31"
FT DOMAIN 4031..4089
FT /note="FIVAR 32"
FT DOMAIN 4157..4218
FT /note="FIVAR 33"
FT DOMAIN 4283..4341
FT /note="FIVAR 34"
FT DOMAIN 4409..4467
FT /note="FIVAR 35"
FT DOMAIN 4535..4592
FT /note="FIVAR 36"
FT DOMAIN 4660..4718
FT /note="FIVAR 37"
FT DOMAIN 4786..4844
FT /note="FIVAR 38"
FT DOMAIN 4912..4970
FT /note="FIVAR 39"
FT DOMAIN 5038..5096
FT /note="FIVAR 40"
FT DOMAIN 5164..5222
FT /note="FIVAR 41"
FT DOMAIN 5290..5344
FT /note="FIVAR 42"
FT DOMAIN 5412..5471
FT /note="FIVAR 43"
FT DOMAIN 5666..5722
FT /note="FIVAR 44"
FT REGION 6616..6713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6616..6694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6695..6713
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6713 AA; 722318 MW; BBCC0536AC341BF5 CRC64;
MGNLQTAIND KSGTLASQNF LDADEQKRNA YNQAISAAET ILNKQTGPNT AKTAVEQALN
NVNSAKHALN GTQNLNNAKQ AAITAINGAS DLNQKQKDAL KAQANGAQRV SNANDVQRNA
TELNTAMGQL QHAIADKTNT LASSKYVNAD STKQNAYTTK VTNAEHIISG TPTVVTTPSE
VTAAANQVNS AKQELNGDER LRVAKQNANT AIDALTQLNT PQKAKLKEQV GQANRLEDVQ
SVQTNGQSLN NAMKGLRDSI ANETTVKASQ NYTDASPNNQ STYNSAVSNA KGIINQTNNP
TMDTSAITQA TTQVNNAKNG LNGAENLRNA QNTAKQNLNT LSHLTNNQKS AISSQIDRAG
HVSEVTAAKN AATELNAQMG NLEQAIHDQN TVKQGVNFTD ADKAKRDAYT NAVSRAETIL
NKTQGANTSK QDVEAAIQNV TSAKNALNGD QNVTNAKNAA KNALNNLTSI NNAQKRDLTT
KIDQATTVAG VEAVSNTGTQ LNTAMANLQN GINDKANTLA SENYHDADSD KKTAYTQAVT
NAENILNKNS GSNLDKAAVE NALSQVTNAK GALNGNHNLE QAKSNANTTI NGLQHLTTAQ
KDKLKQQVQQ AQNVAGVDTV KSSANTLNGA MGTLRNSIQD NTATKNGQNY LDATERNKTN
YNNAVDSANG VINATSNPNM DANAINQIAT QVTSTKNALD GTHNLTQAKQ TATNAIDGAT
NLNKAQKDAL KAQVTSAQRV ANVTSIQQTA NELNTAMGQL QHGIDDENAT KQTQKYRDAE
QSKKTAYDQA VAAAKAILNK QTGSNSDKAA VDRALQQVTS TKDALNGDAK LAEAKAAARQ
NLGTLNHITN AQRTALEGQI NQATTVDGVN TVKTNANTLD GAMNSLQGAI NDKDATLRNQ
NYLDADESKR NAYTQAVTAA EGILNKQTGG NTSKADVDNA LNAVTRAKAA LNGAENLRNA
KTSATNTING LPNLTQLQKD NLKHQVEQAQ NVVGVNGVKD KGNTLNTAMG ALRTSIQNDN
TTKTSQNYLD ASDSNKNNYN TAVNNANGVI NATNNPNMDA NAINDMANQV NTTKAALNGA
QNLAQAKTNA TNTINNAQDL NQKQKDALKT QVNNAQRVSD ANNVQHTATE LNGAMTALKA
AIADKERTKA SGNYVNADQE KRQAYDSKVT NAENIINGTP NATLTVNDVN SAASQVNAAK
TALNGDNNLR VAKEHANNTI DGLAQLNNVQ KAKLKEQVQS ATTLDGVQTV KNSSQTLNTA
MKGLRDSIAN EATIKAGQNY TDASPNNRNE YDSAVTAAKA IINQTSNPTM EPNTITQATS
QVTTKEHALN GAQNLAQAKT TAKNNLNNLT SINNAQKDAL TRNIDGATTV AGVNQETAKA
TELNNAMHSL QNGINDETQT KQTQKYLDAE PSKKSAYDQA VNAAKAILTK ASGQNVDKAA
VEQALQNVNS TKTALNGDAK LNEAKAAAKQ TLGTLTHINN AQRNALDNEI TQATNVEGVN
TVKAKAQQLD GAMGQLETSI RDKDTTLQSQ NYQDADDAKR TAYSQAVNAA ATILNKTAGG
NTPKADVERA MQAVTQANTA LNGIQNLERA KQAANTAITN ASDLNTKQKE ALKAQVTSAG
RVSAANGVEH TATELNTAMT ALKRAIADKA DTKASGNYVN ADANKRQAYD EKVTAAEHIV
SGTPTPTLTP SDVTNAATQV TNAKTQLNGN HNLEVAKQNA NTAIDGLTSL NGPQKAKLKE
QVGQATTLPN VQTVRDNAQT LNTAMKGLRD SIANEATIKA GQNYTDASQN KQNDYNNAVT
AAKAIIGQTT SPSMIAQEIN QAKDQVTAKQ QALNGQENLR TAQTNAKQHL NGLSDLTNAQ
KDAAKRQIEG ATHVNEVTQA QNNADALNTA MTNLKNGIQD QNTIKQGVNF TDADEAKRNA
YTNAVTQAEQ ILNKAQGPNT AKDGVETALQ NVQRAKNELN GNQNVANAKT TAKNALNNLT
SINNAQKAAL KSQIEGATTV AGVNQVSTMA SELNTAMSNL QRGINDEAAT KAAQKYTEAD
RDKQTAYNDA VTAAKTLLDK TAGSNDNKVA VEQALQRVNT AKTALNGDAR LNEAKNTAKQ
QLATMSHLTN AQKANLTEQI ERGTTVAGVQ GIQANAGTLN QAMNQLRQSI ASKDATKSSE
DYQDANADLQ NAYNDAVTNA EGIISATNNP EMNPDTINQK ASQVNSAKSA LNGDEKLAAV
KQTAKSDIGR LTDLNNAQRT AANAEVDQAP NLAAVTAAKN KATSLNTAMG NLKHALAEKD
NTKRSVNYTD ADQPKQQAYD TAVTQAEAIT NANGSNANET QVQAALNQLN QAKNDLNGDN
KVAQAKETAK RALASYSNLN NAQSTAATSQ IDNATTVADV TAAQNTANEL NTAMGQLQNG
INDQNTVKQQ VNFTDADQGK KDAYTNAVTN AQGILDKANG QNMTKAQVEA ALNQVTTAKN
ALNGDANVRQ AKSDAKANLG TLTHLNNAQK QDLTSQIEGA TTVNGVNSVK TKAQDLDGAM
QRLESAIANK DQTKASENYI DADPTKKTAF DNAITQAESY LNKDHGTNKD KQAVEQAIQS
VTSTENALNG DANLQCAKTE ATQAIDNLTQ LNTPQKTALK QQVNAAQRVS GVTDLKNSAT
SLNNAMDQLK QAIGDHDTIV AGGNYTNASP DKQGAYTDAY NAAKNIVNGS PNVITNAADV
TAATQRVNNA ETSLNGDTNL ATAKQQAKDA LRQMTHLSDA QKQSITGQID SATQVTGVQS
VKDNATNLDN AMNQLRNSIA NKDEVKASQP YVDADTDKQN AYNTAVTSAE NIINATSQPT
LDPSAVTQAA NQVNTNKTAL NGAQNLANKK QETTANINRL SHLNNAQKQD LNTQVTNAPN
ISTVNQVKTK AEQLDQAMER LINGIQDKDQ VKQSVNFTDA DPEKQTAYNN AVTAAENIIN
QANGTNANQS QVEAALSTVT TTKQALNGDR KVTDAKNNAN QTLSTLDNLN NAQKGAVTGN
INQAHTVAEV TQAIQTAQEL NTAMGNLKNS LNDKDTTLGS QNFADADPEK KNAYNEAVRN
AENILNKSTG TNVPKDQVEA AMNQVNTTKA ALNGTQNLEK AKQHANTAID GLSHLTNAQK
EALKQLVQQS TTVAEAQGNE QKANNVDAAM DKLRQSIADN ATTKQNQNYT DASPNKKDAY
NNAVTTAQGI IDQTTNPSLD PTVINQAAGQ VSTSKNALNG NENLEAAKQQ ATQSLGSLDN
LNNAQKQAVT NQINGAHTVD EANQIKQNAQ NLNTAMGNLK QAIADKDATK ATVNFTDADQ
AKQQAYNTAV TNAENIISKA NGGNATQTEV EQAIQQVNAA KQALNGNANV QHAKDEATAL
INNSNDLNQA QKDALKQQVQ NATTVAGVNN VKQTAQELNN AMTQLKQGIA DKEQTKADGN
FVNADSDKQN AYNQAVAKAE ALISGTPDVV VTPSEITAAL NKVTQAKNDL NGNTNLATAK
QNVQHAIDQL PNLNQAQRDE YSKQITQATL VPNVNAIQQA ATTLNDAMTQ LKQGIANKAQ
IKGSENYHDA DTDKQTAYDN AVTKAEELLK QTTNPTMDPN TIQQALTKVN DTNQALNGNQ
KLADAKQDAK TTLGTLDHLN DAQKQALTTQ VEQAPDIATV NNVKQNAQNL NNAMTNLNNA
LQDKTETLNS INFTDADQAK KDDYTNAVSH AEGILSKANG SNASQTEVEQ AMQRVNEAKQ
ALNGNDNVQR AKDAAKQVIT NANDLNQAQK DALKQQVDAA QTVANVNTIK QTAQDLNQAM
TQLKQGIADK DQTKANGNFV NADTDKQNAY NNAVAHAEQI ISGTPNANVD PQQVAQALQQ
VNQAKGDLNG NHNLQVAKDN ANTAIDQLPN LNQPQKTALK DQVSHAELVT GVNAIKQNAD
ALNNAMGTLK QQIQANSQVP QSVDFTQADQ DKQQAYNNAA NQAQQIANGT PTPVLAPDTV
TKAVTTMNQA KDALNGDEKL AQAKQDALAN LDTLRDLNQP QRDALRNQIN QAQALATVEQ
TKQNAQNVNT AMGNLKQGIA NKDTVKASEN YHDADVDKQT AYTNAVSQAE GIINQTTNPT
LNPDDITRAL TQVTDAKNSL NGEAKLATEK QNAKDAVSGM THLNDAQKQA LKGQIDQSPE
IATVNQVKQT ATSLDQAMDQ LSQAINDKDQ ILADGNYLNA DPDKQNAYKQ AVAKAEALLN
KQSGTNEVQA QVESITNEVN AAKQALNGND NLANAKQQAK QQLANLTHLN DAQKQSFESQ
ITQAPLVTDV TTINQKAQTL DHAMELLRNS VADNQTTLAS EDYHDATAQR QNDYNKAVTA
ANNIINQTTS PTMNPDDVNG ATTQVNNTKV ALDGDENLAA AKQQANNRLD QLDHLNNAQK
QQLQSQITQS SDIAAVNGHK QTAESLNTAM GNLINAIADH QAVEQRGNFI NADTDKQTAY
NTAVNEAAAM INKQTGQNAN QTEVEQAITK VQTTLQALNG DHNLQVAKTN ATQAIDVLTS
LNDPQKTALK DQVTAATLVT AVHQIEQNAN TLNQAMHGLR QSIQDNAATK ANSKYINEDQ
PEQQNYDQAV QAANNIINEQ TATLDNNAIN QVAATVNTTK AALHGDVKLQ NDKDHAKQTV
SQLAHLNNAQ KHMEDTLIDS ETTRTAVKQD LTEVQALDQL MDALQQSIAD KDATRASSAY
VNAEPNKKQA YDEAVQNAES IIAGLNNPTI NKGNVSSATQ AVISSKNALD GVERLAQDKQ
TAGNSLNHLD QLTPAQQQAL ENQINNATTC DKVAEIIAQA QALNEAMKAL KESIKDQPQT
EASSKFINED QAQKDAYTQA VQHAKDLINK TTDPTLAKSI IDQATQAVTD AKNNLHGDQK
LAQDKQRATE TLNNLSNLNT PQRQALENQI NNAATRGEVA QKLTEAQALN QAMEALRNSI
QDQQQTESGS KFINEDKPQK DAYQAAVQNA KDLINQTGNP TLDKAQVEQL THAFKQAKDN
LHGDQKLADD KQHAVTDLNQ LNGLNNPQRQ ALESQINNAA TRGEVAQKLA EAKALDQAMQ
ALRNSIQDQQ QTEAGSKFIN EDKPQKDAYQ AAVQNAKDLI NQTGNPTLDK SQVEQLTQAV
TTAKDNLHGD QKLARDQQQA VTTVNALPNL NHAQQQTLTD AINAAPTRTE VAQHVQTATE
LDHAMETLKN KVDQVNTDKA QPNYTEASTD KKEAVDQALQ AAQSITDPTN GSNANKDAVE
QALTKLQEKV NELNGNERVA EAKTQAKQTI DQLTHLNADQ IATAKQNIDQ ATKLQPIAEL
VDQATQLNQS MDQLQQAVNE HANVEQTIDY TQADSDKQKA YKQAIADAEN VLKQNANKQQ
VDQALQNILN AKQALNGDER VALAKTNGKH DIDQLNALNN AQQDGFKGRI DQSNDLNQIQ
QIVDEAKALN RAMDQLSQEI TGNEGRTKGS TNYVNADTQV KQVYDEAVDK AKQALDKSSG
QNLTAEQVIK LNDAVTAAKK ALNGEERLNN RKAEALQRLD QLTHLNNAQR QLAIQQINNA
ETLNKASRAI NRATKLDNAM GAVQQYIDEQ HLGVISSTNY INADDNLKAN YDNAIANAAH
ELDKVQGNAI AKAEAEQLKQ NIIDAQNALN GDQNLANAKD KANAFVNSLN GLNQQQQDLA
HKAINNADTV SDVTDIVNNQ IDLNDAMETL KHLVDNEIPN AEQTVNYQNA DDNAKTNFDD
AKRLANTLLN SDNTNVNDIN GAIQAVNDAI HNLNGDQRLQ DAKDKAIQSI NQALANKLKE
IEASNATDQD KLIAKNKAEE LANSIINNIN KATSNQAVSQ VQTAGNHAIE QVHANEIPKA
KIDANKDVDK QVQALIDEID RNPNLTDKEK QALKDRINQI LQQGHNDINN ALTKEEIEQA
KAQLAQALQD IKDLVKAKED AKQDVDKQVQ ALIDEIDQNP NLTDKEKQAL KDRINQILQQ
GHNGINNAMT KEEIEQAKAQ LAQALKEIKD LVKAKENAKQ DVDKQVQALI DEIDQNPNLT
DKEKQALKDR INQILQQGHN DINNAMTKEE IEQAKAQLAQ ALQDIKDLVK AKEDAKNAIK
ALANAKRDQI NSNPDLTPEQ KAKALKEIDE AEKRALQNVE NAQTIDQLNR GLNLGLDDIR
NTHVWEVDEQ PAVNEIFEAT PEQILVNGEL IVHRDDIITE QDILAHINLI DQLSAEVIDT
PSTATISDSL TAKVEVTLLD GSKVIVNVPV KVVEKELSVV KQQAIESIEN AAQQKIDEIN
NSVTLTLEQK EAAIAEVNKL KQQAIDHVNN APDVHSVEEI QQQEQAYIEQ FNPEQFTIEQ
AKSNAIKSIE DAIQHMIDEI KARTDLTDKE KQEAIAKLNQ LKEQAIQAIQ RAQSISEITE
QLEQFKAQMK AANPTAKELA KRKQEAISRI KDFSNEKINS IRNSEIGTAD EKQAAMNQIN
EIVLETIRDI NNAHTLQQVE AALNNGIARI SAVQIVISDR AKQSSSTGNE SNSHLTIGYG
TANHPFNSST IGHKKKLDED DDIDPLHMRH FSNNFGNVIK NAIGVVGISG LLASFWFFIA
KRRRKEDEEE ELEIRDNNKD SIKETLDDTK HLPLLFAKRR RKEDEEDVTV EEKDSLNNGE
SLDKVKHTPF FLPKRRRKED EEDVEVTNEN TDEKVLKDNE HSPLLFAKRR KDKEEDVETT
TSIESKDEDV PLLLAKKKNQ KDNQSKDKKS ASKNTSKKVA AKKKKKKSKK NKK
